Name: Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (scFv-Fc-scFv)
SKU: BSTF-028
Rating: 5 (1 reviews)

Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-CCR3 scFv is fused to the N-terminus of Fc via a hinge region while another anti-CD300 scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb canreduce eosinophil signaling, inhibit bronchoalveolar lavage fluid inflammation, eosinophil, mast cell mediator release and reverse lung inflammation. It is designed for the research of Asthma therapy.

Datasheet INQUIRY

Specifications

Targets

CCR3 & CD300

Type

scFv-Fc-scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Asthma

Host Animal 1

Mouse

Host Animal 2

Mouse

Targets

Target 1

CCR3

Gene ID

1232

UniProt ID

P51677

Alternative Names

CCR3; C-C motif chemokine receptor 3; CKR3; CD193; CMKBR3; CC-CKR-3

Target 2

CD300

Gene ID

11314

UniProt ID

Q9UGN4

Alternative Names

CD300A; CD300a molecule; IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (scFv-Fc-scFv) (CAT#: BSTF-028)

Specifications

Targets

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