Native Human Complement Factor H Protein(Cat#: CTP-458)
This product is a Human factor H protein which is purified from normal human serum. It is an essential regulatory component of the alternative pathway of complement. It has two functional activities: 1) it controls the formation and decay of the alternative pathway C3/C5 convertase (decay accelerating activity) and 2) it acts as a cofactor for factor I which proteolytically inactivates C3b when C3b is bound to factor H (cofactor activity).
Summary
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Specifications
| Specie Reactivity |
Human |
| Target |
Factor H |
| Molecule Mass |
155 kDa |
| Purity |
>95% determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
10 mM Sodium phosphate, 145 mM NaCl, pH 7.3 |
| Applications |
Functional Assays |
| Product Form |
Frozen liquid |
| Storage |
Store at -20°C/-80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. |
| Alternative Names |
Complement Factor H; Age-Related Maculopathy Susceptibility 1; H Factor (Complement); Beta-1H; FHL1 ; Adrenomedullin Binding Protein; Beta-1-H-Globulin; H Factor; Factor H; CFH; FH |
| Gene ID |
3075 |
| UniProt ID |
P08603 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
