Reporter-encoding Oncolytic Vaccinia Virus Western Reserve (ΔE3L), p7.5k-(lacZ) (RepOV-0010WQ)

This product is a lacZ encoding oncolytic vaccinia virus, which is based on VACV-WR with E3L deleted.Protein E3 plays a role in the inhibition of multiple cellular antiviral responses activated by dsRNA, such as inhibition of PKR activation, apoptosis, and IFN-mediated antiviral activities.The TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation.The deletion of E3L and oncolytic-rendered modifications could enhance an immune response to a poxvirus vaccine.This product can be used in oncolytic virotherapy research and vaccinie application.

Specifications
Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR(ΔE3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔE3L
Promoter p7.5k
Transgene lacZ
Type of Transgene Reporter gene
Related Target/Protein Beta-galactosidase
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Breast cancer, Prostate cancer, Colon cancer, Cancer vaccine
Transgene
Alternative Names lacZ, b0344, ECK0341, beta-galactosidase
Gene ID 945006
Information
Introduction The lac operon (lactose operon) is an operon required for the transport and metabolism of lactose in Escherichia coli and many other enteric bacteria. The gene product of lacZ is β-galactosidase which cleaves lactose, a disaccharide, into glucose and galactose.
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