Reporter-encoding Oncolytic Vaccinia Virus Western Reserve (ΔE3L), p7.5k-(EGFP) (RepOV-0008WQ)
This product is a EGFP encoding oncolytic vaccinia virus, which is based on VACV-WR with E3L deleted.Protein E3 plays a role in the inhibition of multiple cellular antiviral responses activated by dsRNA, such as inhibition of PKR activation, apoptosis, and IFN-mediated antiviral activities.The TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation.The deletion of E3L and oncolytic-rendered modifications could enhance an immune response to a poxvirus vaccine.This product can be used in oncolytic virotherapy research and vaccinie application.
Specifications | |
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Family | Poxviridae |
Species | Vaccinia virus |
Serotype | Western Reserve |
Backbone | VACV-WR(ΔE3L) |
Backbone Background | VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies. |
Gene Modification | ΔE3L |
Promoter | p7.5k |
Transgene | EGFP |
Type of Transgene | Reporter gene |
Related Target/Protein | Enhanced green fluorescent protein |
Capsid Modification | None |
Titer | >1*10^8 PFU |
Related Diseases | Breast cancer, Prostate cancer, Colon cancer, Cancer vaccine |
Transgene | |
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Alternative Names | EGFP, egfp, enhanced green fluorescent protein |
Gene ID | 20473140 |
Information | |
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Introduction | EGFP, derived from Aequorea victoria, is a unique GFP variant which contains chromophore mutations that make the protein 35 times brighter than wild-type GFP, and is codon-optimized for higher expression in mammalian cells. These changes in the GFP coding sequence provide an enhanced GFP (EGFP) that greatly increases the sensitivity of the reporter protein. |
All services and products are for lab research only, not for any clinical use.
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