Reporter-encoding Oncolytic Vaccinia Virus Western Reserve (ΔE3L), p7.5k-(EGFP) (RepOV-0008WQ)
DatasheetThis product is a EGFP encoding oncolytic vaccinia virus, which is based on VACV-WR with E3L deleted.Protein E3 plays a role in the inhibition of multiple cellular antiviral responses activated by dsRNA, such as inhibition of PKR activation, apoptosis, and IFN-mediated antiviral activities.The TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation.The deletion of E3L and oncolytic-rendered modifications could enhance an immune response to a poxvirus vaccine.This product can be used in oncolytic virotherapy research and vaccinie application.
| Specifications | |
|---|---|
| Family | Poxviridae |
| Species | Vaccinia virus |
| Serotype | Western Reserve |
| Backbone | VACV-WR(ΔE3L) |
| Backbone Background | VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies. |
| Gene Modification | ΔE3L |
| Promoter | p7.5k |
| Transgene | EGFP |
| Type of Transgene | Reporter gene |
| Related Target/Protein | Enhanced green fluorescent protein |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Breast cancer, Prostate cancer, Colon cancer, Cancer vaccine |
| Transgene | |
|---|---|
| Alternative Names | EGFP, egfp, enhanced green fluorescent protein |
| Gene ID | 20473140 |
| Information | |
|---|---|
| Introduction | EGFP, derived from Aequorea victoria, is a unique GFP variant which contains chromophore mutations that make the protein 35 times brighter than wild-type GFP, and is codon-optimized for higher expression in mammalian cells. These changes in the GFP coding sequence provide an enhanced GFP (EGFP) that greatly increases the sensitivity of the reporter protein. |
All services and products are for lab research only, not for any clinical use.
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