Reporter-encoding Oncolytic Vaccinia Virus Western Reserve (ΔE3L), p11k-(luciferase) (RepOV-0005WQ)

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Reporter-encoding Oncolytic Vaccinia Virus Western Reserve (ΔE3L), p11k-(luciferase) (RepOV-0005WQ)

This product is a luciferase encoding oncolytic vaccinia virus, which is based on VACV-WR with E3L deleted.Protein E3 plays a role in the inhibition of multiple cellular antiviral responses activated by dsRNA, such as inhibition of PKR activation, apoptosis, and IFN-mediated antiviral activities.The TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation.The deletion of E3L and oncolytic-rendered modifications could enhance an immune response to a poxvirus vaccine.This product can be used in oncolytic virotherapy research and vaccinie application.

Specifications
Family	Poxviridae
Species	Vaccinia virus
Serotype	Western Reserve
Backbone	VACV-WR(ΔE3L)
Backbone Background	VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification	ΔE3L
Promoter	p11k
Transgene	luciferase
Type of Transgene	Reporter gene
Related Target/Protein	Luciferase
Capsid Modification	None
Titer	>1*10^8 PFU
Related Diseases	Breast cancer, Prostate cancer, Colon cancer, Cancer vaccine

Transgene
Alternative Names	luciferase, Fluc

Information
Introduction	Luciferase is a generic term for the class of oxidative enzymes that produce bioluminescence, and is usually distinguished from a photoprotein. Luciferases are widely used in biotechnology, for microscopy and as reporter genes, for many of the same applications as fluorescent proteins. However, unlike fluorescent proteins, luciferases do not require an external light source, but do require addition of luciferin, the consumable substrate.

Information

Introduction

Luciferase is a generic term for the class of oxidative enzymes that produce bioluminescence, and is usually distinguished from a photoprotein. Luciferases are widely used in biotechnology, for microscopy and as reporter genes, for many of the same applications as fluorescent proteins. However, unlike fluorescent proteins, luciferases do not require an external light source, but do require addition of luciferin, the consumable substrate.

All services and products are for lab research only, not for any clinical use.

Reporter-encoding Oncolytic Vaccinia Virus Western Reserve (ΔE3L), p11k-(luciferase) (RepOV-0005WQ)

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