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Ang2 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H194 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Tandem Diabody) Human Tandem Diabody Ang2 Human VEGFA Human Inquiry
T-BSDB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem Diabody) Human Tandem Diabody Ang2 Mouse VEGFA Mouse Inquiry
SCIGG-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scIgG) Human Single chain IgGs Ang2 Human VEGFA Human Inquiry
FABVC-358 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-sdAb-Fc) Human Fab-scFv/sdAb-Fc Ang2 Mouse VEGFA llama Inquiry
BSSG-358 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (sdAb-IgG) Human sdAb-IgG Ang2 Mouse VEGFA llama Inquiry
HCAB-003 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (sdAb-Fc-sdAb) Human sdAb-Fc-sdAb Ang2 llama VEGFA llama Inquiry
BIBD-358 Recombinant Anti-Ang2 x Anti-VEGFA VHH BispecificAntibody (Bibody) Human Bibody Ang2 Mouse VEGFA llama Inquiry
IGVHH-003 Recombinant Anti-Ang2 x Anti-VEGFA sdAb Bispecific Antibody (IgG-sdAb) Human IgG-sdAb Ang2 Mouse VEGFA llama Inquiry
SCIGG-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scIgG) Human Single chain IgGs Ang2 Mouse VEGFA Mouse Inquiry
BIVHH-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Bi-sdAb) Human Bi-sdAb Ang2 llama VEGFA llama Inquiry
FVTIG-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scFv4-Ig) Human scFv4-Ig Ang2 Human VEGFA Human Inquiry
FVTIG-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv4-Ig) Human scFv4-Ig Ang2 Mouse VEGFA Mouse Inquiry
BSSG-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scFv-IgG) Human scFv-IgG Ang2 Human VEGFA Human Inquiry
BSSG-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-IgG) Human scFv-IgG Ang2 Mouse VEGFA Mouse Inquiry
IGLFV-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv Ang2 Human VEGFA Human Inquiry
IGLFV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv Ang2 Mouse VEGFA Mouse Inquiry
BSGV-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (IgG-Fv) Human IgG-Fv Ang2 Mouse VEGFA Mouse Inquiry
BSGV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG-Fv) Human IgG-Fv Ang2 Mouse VEGFA Mouse Inquiry
BSDG-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Fv-IgG) Human Fv-IgG Ang2 Human VEGFA Human Inquiry
BSDG-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fv-IgG) Human Fv-IgG Ang2 Mouse VEGFA Mouse Inquiry
BABFV-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 Ang2 Human VEGFA Human Inquiry
BABFV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 Ang2 Mouse VEGFA Mouse Inquiry
FABVC-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc Ang2 Human VEGFA Human Inquiry
FABVC-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc Ang2 Mouse VEGFA Mouse Inquiry
SCDBC-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 Ang2 Human VEGFA Human Inquiry
SCDBC-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 Ang2 Mouse VEGFA Mouse Inquiry
BSDBC-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 Ang2 Human VEGFA Human Inquiry
BSDBC-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 Ang2 Mouse VEGFA Mouse Inquiry
SCDBF-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc Ang2 Human VEGFA Human Inquiry
SCDBF-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc Ang2 Mouse VEGFA Mouse Inquiry
BSFVF-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc Ang2 Human VEGFA Human Inquiry
BSFVF-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc Ang2 Mouse VEGFA Mouse Inquiry
BSDBF-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Diabody-Fc) Human Diabody-Fc Ang2 Human VEGFA Human Inquiry
BSDBF-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Diabody-Fc) Human Diabody-Fc Ang2 Mouse VEGFA Mouse Inquiry
BSTF-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv Ang2 Mouse VEGFA Mouse Inquiry
BSTF-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv Ang2 Mouse VEGFA Mouse Inquiry
BSCFV-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scFv-Fc) Human scFv-Fc Ang2 Mouse VEGFA Mouse Inquiry
BSCFV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-Fc) Human scFv-Fc Ang2 Mouse VEGFA Mouse Inquiry
MNAB-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Miniantibody) Human Miniantibody Ang2 Mouse VEGFA Mouse Inquiry
MNAB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Miniantibody) Human Miniantibody Ang2 Mouse VEGFA Mouse Inquiry
BSFC-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scFv-CH3) Human scFv-CH3 Ang2 Mouse VEGFA Mouse Inquiry
BSFC-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-CH3) Human scFv-CH3 Ang2 Mouse VEGFA Mouse Inquiry
BSCC-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Ang2 Mouse VEGFA Mouse Inquiry
BSCC-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Ang2 Mouse VEGFA Mouse Inquiry
BIBD-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Bibody) Human Bibody Ang2 Mouse VEGFA Mouse Inquiry
BIBD-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Bibody) Human Bibody Ang2 Mouse VEGFA Mouse Inquiry
FABFV-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Fab-Fv) Human Fab-Fv Ang2 Human VEGFA Human Inquiry
FABFV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-Fv) Human Fab-Fv Ang2 Mouse VEGFA Mouse Inquiry
MiniB-H196 Recombinant Human Anti-Ang2 x Human Anti-VEGFA Bispecific Antibody (Minibody) Human Minibody Ang2 Human VEGFA Human Inquiry
MiniB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Minibody) Human Minibody Ang2 Mouse VEGFA Mouse Inquiry
SCDB-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ang2 Human VEGFA Human Inquiry
FABIG-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-IgG) Human Fab-IgG Ang2 Human VEGFA Human Inquiry
TRIB-H196 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv Ang2 Human VEGFA Human Inquiry
BSIG-H194 Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG-IgG) Human IgG-IgG Ang2 Human VEGFA Human Inquiry
CROSSAB-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (CrossMab) Human CrossMab Ang2 Human VEGFA Human Inquiry
IGFV-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG-scFv) Human IgG-scFv Ang2 Human VEGFA Human Inquiry
BSDB-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Diabody) Human Diabody Ang2 Human VEGFA Human Inquiry
BSFAB-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem Fab) Human Tandem Fab Ang2 Human VEGFA Human Inquiry
BSFV-H194 Recombinant Human Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem scFv) Human Tandem scFv Ang2 Human VEGFA Human Inquiry
SCDB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ang2 Mouse VEGFA Mouse Inquiry
FABIG-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-IgG) Human Fab-IgG Ang2 Mouse VEGFA Mouse Inquiry
TRIB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv Ang2 Mouse VEGFA Mouse Inquiry
BSIG-008 Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG-IgG) Human IgG-IgG Ang2 Mouse VEGFA Mouse Inquiry
CROSSAB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (CrossMab) Human CrossMab Ang2 Mouse VEGFA Mouse Inquiry
IGFV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (IgG-scFv) Human IgG-scFv Ang2 Mouse VEGFA Mouse Inquiry
BSDB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Diabody) Human Diabody Ang2 Mouse VEGFA Mouse Inquiry
BSFAB-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem Fab) Human Tandem Fab Ang2 Mouse VEGFA Mouse Inquiry
BSFV-008 Recombinant Anti-Ang2 x Anti-VEGFA Bispecific Antibody (Tandem scFv) Human Tandem scFv Ang2 Mouse VEGFA Mouse Inquiry

Background

Angiopoietin-2 (Ang2) is one of the principal growth factors involved in angiogenesis, differing from Angiopoietin-1 (Ang1) in that it primarily functions via autocrine signaling and does not bind with the Tie1 receptor. Under physiological conditions, Ang2 inhibits the Tie2 phosphorylation induced by Ang1, and phosphorylates Tie2 at a lower intensity, thereby inducing endothelial cell function and promoting lymphatic growth. Additionally, research suggests that Ang2 functions via integrins as alternative receptors.

Furthermore, Ang2 plays a central role in diseases related to vascular permeability and angiogenesis. During inflammatory conditions or tumor progression, upregulated Ang2 expression increases the permeability of endothelial cells, induces pericyte detachment from the basal lamina, which leads to vascular leakage, and promotes tumor proliferation and metastasis, consequently exacerbating disease conditions.

Ang2 signaling. (Akwii, et al., 2019) Fig.1 Ang2 signaling.1

Reference

  1. Akwii, Sajib, et al. " Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology." Cells. 8 (2019): 471.
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