Recombinant Anti-EGFR x Anti-HER3 Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the abrin-a A chain (ABRa-A) fused to a tandem Fab recognizing EGFR and HER3. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver ABRa-A to antigen-specific cells. Then ABR is a type II ribosome inactivating protein (RIP) and can kill the target cells. The bispecific immunotoxin is designed for the research of Solid tumors therapy.
Welcome! For price inquiries, we will get back to you as soon as possible.
INQUIRY