Anti-ADAM17 Aptamer (CTApt-1005)

Specifications

Target Category	Protein
Target	ADAM17
Alternative Names	ADAM Metallopeptidase Domain 17; CSVP; Disintegrin And Metalloproteinase Domain-Containing Protein 17; Tumor Necrosis Factor, Alpha, Converting Enzyme; Snake Venom-Like Protease; TNF-Alpha Convertase; EC 3.4.24.86; CD156B; TACE; ADAM Metallopeptidase Domain 18; TNF-Alpha Converting Enzyme; TNF-Alpha-Converting Enzyme; CD156b Antigen; ADAM 17; ADAM18; NISBD1; ADAM17; NISBD
Gene ID	6868
UniProt ID	P78536
Target Overview	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.
Chemical Modification	DNA/RNA
Length	20-80 nt
Affinity (Kd)	1nM~1μM
Binding Conditions/Buffer	PBS; buffer system with Serum; other

Anti-ADAM17 Aptamer(Cat#: CTApt-1005)