Anti-ADAMTS8 Aptamer(Cat#: CTApt-1278)
This product is an aptamer which binds to the ADAMTS8 with an affinity of 1nM~1μM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
ADAMTS8 |
| Alternative Names |
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 8; ADAM-TS8; METH2; A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 8; A Disintegrin And Metalloproteinase With Thrombospondin Motifs 8; ADAMTS-8; METH-2; METH-8; EC 3.4.24.82; EC 3.4.24.14; EC 3.4.24.-; ADAM-TS 8; EC 3.4.24; FLJ41712; ADAMTS8 |
| Gene ID |
11095 |
| UniProt ID |
Q9UP79 |
| Target Overview |
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. |
| Chemical Modification |
DNA/RNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
