Anti-ALAD Aptamer(Cat#: CTApt-1120)
This product is an aptamer which binds to the ALAD with an affinity of 1nM~1μM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
ALAD |
| Alternative Names |
Aminolevulinate Dehydratase; Porphobilinogen Synthase; ALADH; Delta-Aminolevulinic Acid Dehydratase; Aminolevulinate, Delta-, Dehydratase; EC 4.2.1.24; PBGS; Testicular Tissue Protein Li 95; ALAD; |
| Gene ID |
210 |
| UniProt ID |
P13716 |
| Target Overview |
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. |
| Chemical Modification |
DNA/RNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
