Anti-ATP2A2 Aptamer(Cat#: CTApt-2403)
This product is an aptamer which binds to the ATP2A2 with an affinity of 1nM~1μM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
ATP2A2 |
| Alternative Names |
ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2; Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2; Calcium Pump 2; SERCA2; Calcium-Transporting ATPase Sarcoplasmic Reticulum Type, Slow Twitch Skeletal Muscle Isoform; Endoplasmic Reticulum Class 1/2 Ca(2+) ATPase; SR Ca(2+)-ATPase 2; ATP2B; ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2; ATPase Ca++ Transporting Cardiac Muscle Slow Twitch 2; ATPase, Ca++ Dependent, Slow-Twitch, Cardiac Muscle-2; Cardiac Ca2+ ATPase; EC 7.2.2.10; EC 3.6.3.8; EC 3.6.3; ATP2A2; DAR; DD |
| Gene ID |
488 |
| UniProt ID |
P16615 |
| Target Overview |
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Chemical Modification |
DNA/RNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
