Anti-ATP6V1B1 Aptamer(Cat#: CTApt-2287)
This product is an aptamer which binds to the ATP6V1B1 with an affinity of 1nM~1μM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
ATP6V1B1 |
| Alternative Names |
ATPase H+ Transporting V1 Subunit B1; VATB; ATPase, H+ Transporting, Lysosomal 56/58kDa, V1 Subunit B1; V-Type Proton ATPase Subunit B, Kidney Isoform; Endomembrane Proton Pump 58 KDa Subunit; Vacuolar Proton Pump Subunit B 1; Vacuolar Proton Pump 3; V-ATPase Subunit B 1; ATP6B1; RTA1B; VPP3; H(+)-Transporting Two-Sector ATPase, 58kD Subunit; Renal Tubular Acidosis With Deafness; Vacuolar Proton Pump, Subunit 3; H+-ATPase Beta 1 Subunit; V-ATPase B1 Subunit; ATP6V1B1; VMA2; Vma2 |
| Gene ID |
525 |
| UniProt ID |
P15313 |
| Target Overview |
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. |
| Chemical Modification |
DNA/RNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
