Anti-AXIN1 Aptamer(Cat#: CTApt-2418)
This product is an aptamer which binds to the AXIN1 with an affinity of 1nM~1μM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
AXIN1 |
| Alternative Names |
Axin 1; Protein Phosphatase 1, Regulatory Subunit 49; Axis Inhibition Protein 1; PPP1R49; Axin-1; AXIN; Fused, Mouse, Homolog Of; Axis Inhibitor 1; AXIN1; HAxin |
| Gene ID |
8312 |
| UniProt ID |
O15169 |
| Target Overview |
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. |
| Chemical Modification |
DNA/RNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
