Anti-BLM aptamer(Cat#: CTApt-1860)
This product is an aptamer which binds to the BLM with an affinity of 1nM~1μM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
BLM |
| Alternative Names |
BLM RecQ Like Helicase; RECQL3; RECQ2; Bloom Syndrome RecQ Like Helicase; DNA Helicase, RecQ-Like Type 2; Bloom Syndrome Protein; RecQ Protein-Like 3; BS; Bloom Syndrome, RecQ Helicase-Like; Bloom Syndrome; EC 3.6.4.12; MGRISCE1; EC 3.6.1; RECQL; RecQ2; BLM |
| Gene ID |
641 |
| UniProt ID |
P54132 |
| Target Overview |
The Bloom syndrome is an autosomal recessive disorder characterized by growth deficiency, microcephaly and immunodeficiency among others. It is caused by homozygous or compound heterozygous mutation in the gene encoding DNA helicase RecQ protein on chromosome 15q26. This Bloom-associated helicase unwinds a variety of DNA substrates including Holliday junction, and is involved in several pathways contributing to the maintenance of genome stability. Identification of pathogenic Bloom variants is required for heterozygote testing in at-risk families. |
| Chemical Modification |
DNA/RNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
