Anti-Human PDGFRB Aptamer(Cat#: CTMM-0124-RJ50)
This product is an aptamer which binds to Human PDGFRB with an affinity of 1-50 nM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
PDGFRB |
| Alternative Names |
Platelet Derived Growth Factor Receptor Beta; PDGFR1; JTK12; PDGFR; Platelet-Derived Growth Factor Receptor, Beta Polypeptide; Beta-Type Platelet-Derived Growth Factor Receptor; Platelet-Derived Growth Factor Receptor Beta; Platelet-Derived Growth Factor Receptor 1; CD140 Antigen-Like Family Member B; PDGF-R-Beta; EC 2.7.10.1; PDGFR-Beta; PDGFR-1; CD140B; Beta Platelet-Derived Growth Factor Receptor; Activated Tyrosine Kinase PDGFRB; CD140b Antigen; NDEL1-PDGFRB; EC 2.7.10; CD140b; IBGC4; PENTT; IMF1; KOGS; PDGFRB |
| Gene ID |
5159 |
| UniProt ID |
P09619 |
| Target Overview |
The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. |
| Chemical Modification |
2'-fluoro pyrimidines |
| Type |
RNA |
| Species Reactivity |
Human |
| Length |
<50 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
10 mM Tris-HCl containing 200 mM NaCl, 5 mM EDTA, 0.1% Triton X-100, and protease inhibitors, pH 7.5 |
| GC Content |
45.71% |
| Molecular Weight |
10105.5 g/mole |
| nmoles/OD260 |
2.648 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
