Anti-Human TARDBP Aptamer(Cat#: CTWZ-0124-WZ53)
This product is an aptamer which binds to human TARDBP with an affinity of 50-200 nM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
TARDBP |
| Alternative Names |
TAR DNA Binding Protein; TDP-43; ALS10; TAR DNA-Binding Protein 43; TAR DNA-Binding Protein-43; TDP43 |
| Gene ID |
23435 |
| UniProt ID |
Q13148 |
| Target Overview |
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. |
| Chemical Modification |
2'-fluoro pyrimidines |
| Type |
RNA |
| Species Reactivity |
Human |
| Length |
<50 nt |
| Affinity (Kd) |
50-200 nM |
| Binding Conditions/Buffer |
10 mM potassium phosphate buffer with 150 mM KCl and 0.01% Tween20, pH 7.2 |
| GC Content |
50.00% |
| Molecular Weight |
2993.9 g/mole |
| nmoles/OD260 |
9.868 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
