Introduction How Can We Help? Deliverables Key Benefits Related Products FAQs Contact
Are you currently facing difficulties achieving active drug transport across the Blood-Brain Barrier (BBB), or designing multifunctional systems for theranostics and regenerative medicine? Our Creative Biolabs ApDCs and Nanoconjugates Service helps you unlock previously inaccessible disease targets and simplify complex delivery challenges through advanced SELEX, precision chemical modification, and optimized nanocarrier conjugation. We accelerate the development of highly specific, low-immunogenic therapeutics for complex biological environments.
Introduction of ApDCs Development for Other Emerging/Multifunctional
ApDCs represent a paradigm shift from traditional antibody-based therapies. Aptamers are small, single-stranded nucleic acids, often termed "chemical antibodies," selected for ultra-high affinity and specificity to virtually any target, including proteins, cells, or even complex tissue microenvironments. This nucleic acid foundation offers significant biological and synthetic advantages that are particularly critical for applications outside of traditional oncology, focusing on areas requiring deep tissue penetration, minimal immunogenicity, and precise localization.
What Is Our Service?
We engineer chemically stable, highly specific aptamer conjugates designed to deliver diverse payloads (drugs, siRNAs, imaging agents) directly to difficult targets, utilizing the inherent low immunogenicity and high modularity of nucleic acid scaffolds.
Application Scenarios of Our Services:
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Neurodegenerative Disease Targeting: We engineer ApDCs capable of active receptor-mediated transcytosis across the Blood-Brain Barrier (BBB). This facilitates the targeted delivery of therapeutics or diagnostics to misfolded proteins that accumulate in the central nervous system, which is essential for treating conditions like Alzheimer's and Parkinson's diseases.
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Multifunctional Theranostics: We create integrated nanoconjugates where the aptamer guides a nanoparticle containing both an imaging agent and a therapeutic payload. This allows for simultaneous detection, targeted delivery, and real-time monitoring of therapeutic response in a single platform.
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Tissue Regeneration and Repair: Our platform is used to deliver regenerative payloads with high specificity directly to damaged tissues, improving localized efficacy and minimizing systemic exposure for applications in cardiology or chronic inflammatory models.
Why Choose Us?
Creative Biolabs leverages the inherent biological and chemical advantages of aptamers to create superior therapeutic agents.
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Pain Points
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Benefit Created by Creative Biolabs
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Inaccessible Targets
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Active Barrier Crossing: We utilize custom dual-targeting aptamers for highly efficient, receptor-mediated transport across the BBB, unlocking high-value therapeutic targets.
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High Immunogenicity & Manufacturing Costs
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Superior Safety and Scalability: ApDCs are non-proteinaceous, minimizing immune risk, and are produced via rapid, cost-effective chemical synthesis, accelerating development timelines.
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Fig.1 Various applications of ApDCs.1
How Creative Biolabs' ApDCs Can Assist Your Project?
Creative Biolabs provides validated, end-to-end development services for aptamer-based therapeutics, ensuring specific deliverables and a streamlined process that minimizes risk and accelerates transition to the clinic.
Workflow of ApDC Development
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Required Starting Materials
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Target Information and Receptor Expression
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Payload and Release Kinetics
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Application Context
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Target Screening & SELEX Optimization
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Chemical Modification & Stabilization
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Precision Bioconjugation & Nanocarrier Loading
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Targeted Delivery Validation
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Quality Control (QC)
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Deliverables
Creative Biolabs ensures the successful completion of your project by providing a thorough and standardized data package:
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Final Conjugate Lot and CoA: High-purity, characterized lot of the ApDC, provided with a Certificate of Analysis (CoA) detailing purity and concentration.
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Comprehensive Analytical Lab Report: Detailed physical-chemical characterization data and controlled stability testing logs.
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Raw Data Files and Model Annotations: Complete raw data from all binding kinetics assays, cellular uptake studies, and BBB transcytosis validation reports.
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Sequence and Modification Maps: Full annotation of the final aptamer sequence, including precise location and type of chemical modifications.
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Standard Operating Procedures (SOPs): Detailed, transferable SOP for the final synthesis, conjugation, and purification process for future scalability.
Key Benefits
The Creative Biolabs ApDCs platform is purpose-built to overcome the most persistent challenges in drug development, positioning your project for therapeutic success in emerging and complex fields.
Active Transcytosis for CNS Access
We specialize in engineering aptamers that actively navigate the BBB, transforming previously inaccessible neurodegenerative targets into viable therapeutic opportunities.
Disruptive Payload Versatility
Our platform supports conjugation to a wider array of payloads—from small molecules and siRNAs to entire nanocarriers—allowing for high-payload delivery and the facile creation of multifunctional theranostic systems.
Minimized Immunogenicity Risk
By relying on nucleic acids instead of large proteins, our ApDCs possess a low inherent immunogenic profile, offering a better safety margin and therapeutic window for chronic treatments.
Engineering for Stability
We implement proprietary chemical stabilization methods and optimized linker chemistry, ensuring the conjugate remains intact in circulation and releases the payload efficiently only at the target site.
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Related Products
Frequently Asked Questions
Q1: How does an ApDC system achieve active delivery across the BBB, which is usually impenetrable?
A: Our ApDCs are engineered to bind highly expressed receptors on the BBB surface. When the ApDC binds, it triggers a natural cellular transport process called receptor-mediated transcytosis, which actively shuttles the conjugate across the barrier. This mechanism is crucial for our success in neuro-targeting projects.
Q2: Since aptamers are nucleic acids, is their stability in vivo a major limitation compared to antibodies?
A: Stability is a valid concern, and we manage it proactively. We integrate non-natural nucleotides during synthesis to make the aptamer highly resistant to nuclease degradation. This chemical stabilization significantly extends the conjugate's plasma half-life to clinically relevant durations, surpassing the limitations of native aptamers.
Q3: How do you ensure the drug is released only at the target site and doesn't detach prematurely in circulation?
A: We prioritize precision linker design. We utilize specific, chemically stable linkers that are selectively cleavable only under the conditions found within the target cell or tumor microenvironment. This minimizes premature drug release and maximizes the conjugate's therapeutic index.
Contact Us
Creative Biolabs provides specialized expertise in the development and manufacturing of Aptamer-Drug for complex, emerging therapeutic areas. We transform delivery challenges into opportunities for highly effective, low-immunogenic precision medicine. Contact our experts, who are available to discuss your specific target and design an optimized ApDC strategy.
Reference
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Gao, Fei, et al. "Recent advances in aptamer-based targeted drug delivery systems for cancer therapy." Frontiers in Bioengineering and Biotechnology 10 (2022): 972933. Distributed under Open Access license CC BY 4.0, without modification. DOI: https://doi.org/10.3389/fbioe.2022.972933
For Research Use Only.
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