Rat Anti-Human CD18 Monoclonal Antibody (CTJS-345)(Cat#: CTA-276)
This product is an unconjugated anti-Human CD18 Monoclonal antibody (CTJS-345) generated from the Rat. The antibody can be used for FC; ICC/IF; IHC; IP.
Summary
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Specifications
| Clonality |
Monoclonal |
| Clone |
CTJS-345 |
| Host Animal |
Rat |
| Isotype |
IgG2b |
| Immunogen |
Human neutrophils |
| Species Reactivity |
Human; Canine; Guinea Pig |
| Applications |
FC; ICC/IF; IHC; IP |
| Application Notes |
FC: 1:50-1:100
IF: 1:10-1:500
IHC: 1:10-1:500
IP: 1:10-1:500
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Human, Canine, Guinea Pig CD18. |
| Purity |
≥95% as determined by SDS-PAGE |
| Format |
Liquid |
| Size |
25; 100 µg |
| Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Type |
Primary Antibody |
Target
| Target Name |
CD18 |
| Alternative Names |
Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD_antigen: CD18; Leukocyte Cell Adhesion Molecule CD18; Complement Receptor C3 Beta-Subunit; Macrophage Antigen 1 (Mac-1) Beta Subunit); LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1 |
| Gene ID |
3689 |
| UniProt ID |
P05107 |
Information
| Introduction |
In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one of a number of alpha chains, CD18 is capable of forming multiple heterodimers, which play significant roles in cellular adhesion and cell surface signaling, as well as important roles in immune responses. CD18 also exists in soluble, ligand binding forms. Deficiencies in CD18 expression can lead to adhesion defects in circulating white blood cells in humans, reducing the immune system's ability to fight off foreign invaders. The ITGB2 protein product is CD18. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain, and are crucial for cells to be able to efficiently bind to the extracellular matrix. This is especially important for neutrophils, as cellular adhesion plays a large role in extravasation from the blood vessels. A given chain may combine with multiple partners resulting in different integrins. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
