NCI-H596 In Vitro TRAP Assay (Senescence)

This assay is to provide NCI-H596-based In Vitro TRAP Assay (Senescence) to accelerate our client's oncology projects. The assay will be customized according to the specific requirements. Please contact our scientists to discuss more details.

NCI-H596

Human

The NCI-H596 cell line was derived by A.F. Gazdar and H. Oie in 1983 from a tumor mass in the chest wall of a patient with adenosquamous carcinoma of the lung. The specimen was obtained prior to therapy.

Adenosquamous Carcinoma

Oncology

In Vitro TRAP Assay (Senescence)

The telomerase repeated amplification protocol (TRAP) assay is one of the common PCR-based assays used to detect telomerase activity in cells.

Telomerase Repeated Amplification Protocol Assay

Cellular Senescence in Cancer Assays

Cell senescence is described as an irreversible physiological event of cell growth arrest, which is known to be caused by alterations of telomeres, oxidative stress, DNA damage and some oncogenes. Inhibition of the program of senescence is one of the main features of tumor cells and it has been reported that cancer cells can be induced to undergo senescence by chemo- and radiotherapies and genetic alterations. Telomeres help to prevent uncontrolled cell proliferation and the absence of telomeres results in aneuploidy and cell death.

TRAP Assay