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Kit Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H343 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody Kit Human VCAM-1 Human Inquiry
T-BSDB-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody Kit Mouse VCAM-1 Mouse Inquiry
SCIGG-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (scIgG) Human Single chain IgGs Kit Human VCAM-1 Human Inquiry
SCIGG-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (scIgG) Human Single chain IgGs Kit Mouse VCAM-1 Mouse Inquiry
FVTIG-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig Kit Human VCAM-1 Human Inquiry
FVTIG-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig Kit Mouse VCAM-1 Mouse Inquiry
BSSG-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (scFv-IgG) Human scFv-IgG Kit Human VCAM-1 Human Inquiry
BSSG-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (scFv-IgG) Human scFv-IgG Kit Mouse VCAM-1 Mouse Inquiry
IGLFV-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv Kit Human VCAM-1 Human Inquiry
IGLFV-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv Kit Mouse VCAM-1 Mouse Inquiry
BSGV-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (IgG-Fv) Human IgG-Fv Kit Human VCAM-1 Human Inquiry
BSGV-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (IgG-Fv) Human IgG-Fv Kit Mouse VCAM-1 Mouse Inquiry
BSDG-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (Fv-IgG) Human Fv-IgG Kit Human VCAM-1 Human Inquiry
BSDG-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Fv-IgG) Human Fv-IgG Kit Mouse VCAM-1 Mouse Inquiry
BABFV-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 Kit Human VCAM-1 Human Inquiry
BABFV-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 Kit Mouse VCAM-1 Mouse Inquiry
FABVC-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc Kit Human VCAM-1 Human Inquiry
FABVC-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc Kit Mouse VCAM-1 Mouse Inquiry
SCDBC-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 Kit Human VCAM-1 Human Inquiry
SCDBC-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 Kit Mouse VCAM-1 Mouse Inquiry
BSDBC-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 Kit Human VCAM-1 Human Inquiry
BSDBC-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 Kit Mouse VCAM-1 Mouse Inquiry
SCDBF-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc Kit Human VCAM-1 Human Inquiry
SCDBF-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc Kit Mouse VCAM-1 Mouse Inquiry
BSFVF-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc Kit Human VCAM-1 Human Inquiry
BSFVF-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc Kit Mouse VCAM-1 Mouse Inquiry
BSDBF-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc Kit Human VCAM-1 Human Inquiry
BSDBF-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc Kit Mouse VCAM-1 Mouse Inquiry
BSTF-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv Kit Human VCAM-1 Human Inquiry
BSTF-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv Kit Mouse VCAM-1 Mouse Inquiry
BSCFV-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (scFv-Fc) Human scFv-Fc Kit Human VCAM-1 Human Inquiry
BSCFV-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (scFv-Fc) Human scFv-Fc Kit Mouse VCAM-1 Mouse Inquiry
MNAB-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (Miniantibody) Human Miniantibody Kit Human VCAM-1 Human Inquiry
MNAB-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Miniantibody) Human Miniantibody Kit Mouse VCAM-1 Mouse Inquiry
BSFC-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (scFv-CH3) Human scFv-CH3 Kit Human VCAM-1 Human Inquiry
BSFC-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (scFv-CH3) Human scFv-CH3 Kit Mouse VCAM-1 Mouse Inquiry
BSCC-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Kit Human VCAM-1 Human Inquiry
BSCC-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Kit Mouse VCAM-1 Mouse Inquiry
BIBD-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (Bibody) Human Bibody Kit Human VCAM-1 Human Inquiry
BIBD-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Bibody) Human Bibody Kit Mouse VCAM-1 Mouse Inquiry
FABFV-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (Fab-Fv) Human Fab-Fv Kit Human VCAM-1 Human Inquiry
FABFV-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Fab-Fv) Human Fab-Fv Kit Mouse VCAM-1 Mouse Inquiry
MiniB-H344 Recombinant Human Anti-Kit x Human Anti-VCAM-1 Bispecific Antibody (Minibody) Human Minibody Kit Human VCAM-1 Human Inquiry
MiniB-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Minibody) Human Minibody Kit Mouse VCAM-1 Mouse Inquiry
SCDB-H343 Recombinant Human Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Kit Human VCAM-1 Human Inquiry
FABIG-H343 Recombinant Human Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Fab-IgG) Human Fab-IgG Kit Human VCAM-1 Human Inquiry
TRIB-H345 Recombinant Human Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv Kit Human VCAM-1 Human Inquiry
BSIG-H343 Human Anti-Kit x Anti-VCAM-1 Bispecific Antibody (IgG-IgG) Human IgG-IgG Kit Human VCAM-1 Human Inquiry
CROSSAB-H343 Recombinant Human Anti-Kit x Anti-VCAM-1 Bispecific Antibody (CrossMab) Human CrossMab Kit Human VCAM-1 Human Inquiry
IGFV-H343 Recombinant Human Anti-Kit x Anti-VCAM-1 Bispecific Antibody (IgG-scFv) Human IgG-scFv Kit Human VCAM-1 Human Inquiry
BSDB-H343 Recombinant Human Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Diabody) Human Diabody Kit Human VCAM-1 Human Inquiry
BSFAB-H343 Recombinant Human Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Tandem Fab) Human Tandem Fab Kit Human VCAM-1 Human Inquiry
BSFV-H341 Recombinant Human Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Tandem scFv) Human Tandem scFv Kit Human VCAM-1 Human Inquiry
SCDB-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Kit Mouse VCAM-1 Mouse Inquiry
FABIG-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Fab-IgG) Human Fab-IgG Kit Mouse VCAM-1 Mouse Inquiry
TRIB-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv Kit Mouse VCAM-1 Mouse Inquiry
BSIG-179 Anti-Kit x Anti-VCAM-1 Bispecific Antibody (IgG-IgG) Human IgG-IgG Kit Mouse VCAM-1 Mouse Inquiry
CROSSAB-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (CrossMab) Human CrossMab Kit Mouse VCAM-1 Mouse Inquiry
IGFV-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (IgG-scFv) Human IgG-scFv Kit Mouse VCAM-1 Mouse Inquiry
BSDB-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Diabody) Human Diabody Kit Mouse VCAM-1 Mouse Inquiry
BSFAB-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Tandem Fab) Human Tandem Fab Kit Mouse VCAM-1 Mouse Inquiry
BSFV-179 Recombinant Anti-Kit x Anti-VCAM-1 Bispecific Antibody (Tandem scFv) Human Tandem scFv Kit Mouse VCAM-1 Mouse Inquiry

Background

Fig 1. Activation of CD117 activates multiple signaling pathways. (Foster, et al., 2018)Fig.1 Activation of CD117 activates multiple signaling pathways.1

Kit, also called CD117 or stem cell factor receptor (SCFR), is a tyrosine kinase receptor that is required for the growth and development of various cell types. It is the receptor for stem cell factor (SCF), and its activation is essential for cell survival, proliferation, and differentiation. Upon binding with its ligand SCF, Kit dimerizes and autophosphorylates, triggering a cascade of downstream signaling pathways, including the PI3K/AKT and MAPK pathways, which regulate cellular processes such as growth and apoptosis. Clinically, Kit is significant in the field of oncology, as mutations in Kit can lead to abnormal cell proliferation and are associated with various cancers, including gastrointestinal stromal tumors (GISTs). Kit inhibitorshave been developed as targeted therapies to treat cancers with aberrant Kit signaling. Additionally, Kit is used as a marker in stem cell research and in the diagnosis of certain hematopoietic and mast cell disorders.

Reference

  1. Foster, Brittni M, et al. “CD117/c-kit in Cancer Stem Cell-Mediated Progression and Therapeutic Resistance.” Biomedicines vol. 6,1 31. 8 Mar. 2018.
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