Creative Biolabs is one of the well-recognized experts who are professionals in aptamer development. To meet your specific aptamer discovery and development project's needs, we offer a series of services in a high-quality manner. We would be pleased to provide support for any of your questions.
Different Application Areas of Aptamer
Aptamers with their high specificity, versatile function, low immunogenicity, and relatively low production cost, represent the next generation of therapeutics that deserve their spotlight in the clinic. More significantly, the convenience ability of aptamers in conjugation with various functional moieties and the extensive scope of their potential biological ligands make aptamers a promising targeting tool in the development of the targeted delivery system. Moreover, the chemical plasticity of aptamers allows for the addition of reporter groups that are used as sensors in diagnosis. Due to their specificity, stability, and versatility, aptamers are promising in diagnostics and therapeutics.
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Aptamer for Targeted Delivery
Aptamers have been used successfully to deliver a variety of therapeutic reagents into the target cells and tissues. By attaching drugs, aptamers can deliver cargo molecules to or into selected tissues, cell types, or even subcellular organelles. The specific drug delivery system dramatically increases the affinity and specificity of aptamers. Moreover, aptamers are also being utilized to deliver toxins, radioisotopes, and chemotherapeutic agents encapsulated in nanoparticles. The specific delivery of these therapeutic agents offers several benefits, such as a simple and affordable manufacturing process without using organic solvents or potentially toxic ingredients, high stability, and high carrier capacity.
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Aptamer for Biomarker Discovery
Using complex samples as targets, a panel of aptamers can be systematically generated for comprehensive recognition of disease-specific proteins, potentially serving as biomarkers. Aptamers recognize their cognate targets with selectivity and affinity comparable to that of protein antibodies. In addition, aptamers have superiorities, including easy synthesis, high chemical stability, convenient modification, and flexible design. As such, these molecules show great promise as powerful molecular probes for biomarker discovery and biomarker-based clinical applications.
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Aptamer for Diagnostics
Aptamers are applicable tools in detecting and defending against unknown pathogens (bacterial, fungal, and viral agents). To date, aptamers have been successively used instead of monoclonal antibodies in flow cytometry, immunochemical sandwich assays, and in vivo imaging as well to detect a wide range of small or large biomolecules. In terms of diagnostics, aptamer is a convincing substitute and offers the opportunity to develop ideal diagnostic agents in clinical diagnosis.
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Aptamer for Therapeutics
During the last years, aptamer technology is being used in a wide range of therapeutic applications, such as macular degeneration, coagulation, oncology, and inflammation research. Aptamers recognize target through specific and strong interactions superior to other biologics and small molecule therapeutics, with lower toxicity and immunogenicity profiles. As novel targeted molecules, many aptamer-based drugs have been approved. Several aptamers for immune disorders are also in the preclinical stages, including those targeting neurodegenerative diseases, immune disorders, and inflammation.
The use of aptamers in the development of diagnostic platforms or as therapeutic drugs is a promising alternative. Creative Biolabs provides full technical support to all our customers and will never leave you with an unresolved issue. We look forward to discussing your inquiry and finding the best solution for your needs. Please feel free to contact us for more information.
References
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Song, Kyung-Mi, Seonghwan Lee, and Changill Ban. "Aptamers and their biological applications." Sensors 12.1 (2012): 612-631.
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Chang, Yun Min, Michael J. Donovan, and Weihong Tan. "Using aptamers for cancer biomarker discovery." Journal of nucleic acids 2013 (2013).
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Zou, Xinran, et al. "Application of aptamers in virus detection and antiviral therapy." Frontiers in microbiology 10 (2019): 1462.
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