CD11b Blocking Peptide-1(Cat#: CTD-137)
This product is a synthetic peptide that used for blocking the activity of human CD11b antibody.
Summary
Related Products & Services
Specifications
| Sequence |
PFEVPNPLPL IVGSSVGGLL LLALITAALY KLGFFKRQYK DMMSEGGPPG |
| Purity |
>90% |
| Pack Size |
100 μg |
| Format |
Lyophilized |
| Conjugate |
Unconjugated |
| Species Reactivity |
Human |
| Applications |
Blocking; WB |
| Storage |
Short at 4°C for short term and at -20°C for long term. |
Information
| Introduction |
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
