Complement C5 Blocking Peptide(Cat#: CTD-054)
This product is a synthetic peptide that used for blocking the activity of human Complement C5 antibody.
Summary
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Specifications
| Solubility |
Soluble in Water. |
| Purity |
>90% |
| Pack Size |
100 µg |
| Format |
Lyophilized |
| Conjugate |
Unconjugated |
| Species Reactivity |
Human |
| Applications |
Blocking |
| Storage |
Short at 4°C for short term and at -20°C for long term. |
Information
| Introduction |
Complement component 5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. C5 is composed of alpha (C5a) and beta (C5b) polypeptide chains. Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
