Complement receptor 4 (CR4) is defined as a heterodimer of alpha (CD11c) and beta (CD18) transmembrane proteins expressed primarily in neutrophils, monocytes and tissue macrophages. CR4 is a 150 kDa glycoprotein that includes an extracellular domain, a transmembrane segment, and a cytoplasmic tail. CR4 is referred to as a β2 integrin because it contains the same β subunit as leukocyte function-associated molecule 1 (LFA-1). Notably, like CR3, it binds to iC3b. In recent years, with the increasing recognition of our complement products and services by customers, Creative Biolabs has become a world-renowned expert in the complement field. We are willing to share the latest developments in complement research as well as relevant background knowledge.
Complement Receptor CR4 (CD11c/CD18) Purification Protocol
The purification of the CR4 is carried out based on its affinity for iC3b.
Fig.1 Flow chart of CR4 purification protocol. (Creative Biolabs)
Creative Biolabs is a leading complement customization service provider with extensive experience in various complement research projects. Our service portfolio includes antibody development for drug development, inhibitor development, and various complement function testing services. In addition, a wide range of complement products such as sera, inhibitors, proteins and peptides are available at the most competitive prices in the industry. Our experts are ready to discuss with our clients how we can assist you in the development and optimization of your complement research protocol.
Services and Product at Creative Biolabs
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Please note that our protocols are only for your reference!
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