Danicopan(Cat#: CTI-011)
This product is a potent and selective factor D antagonist, it inhibits factor D with the Kd value of 0.54 nM. It also inhibits alternative pathway of complement (APC) activity, and has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
Summary
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Specifications
| CAS No. |
1903768-17-1 |
| Formula |
C₂₆H₂₃BrFN₇O₃ |
| Molecular Weight |
580.41 |
| SMILES |
O=C([C@H]1N(C(CN2N=C(C(C)=O)C3=C2C=CC(C4=CN=C(C)N=C4)=C3)=O)C[C@H](F)C1)NC5=NC(Br)=CC=C5 |
| IC50 |
IC50: 0.54 nM |
| Purity |
98% |
| Solubility |
DMSO :>260 mg/mL (447.96 mM; Need ultrasonic) |
| Storage |
Store at -4°C for short term; at -20 °C for long-term storage. |
| Target |
Factor D |
| Introduction |
The Factor D is a member of the trypsin family of peptidases. It is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
