Human Complement C5a ELISA Kit-CTK-319(Cat#: CTK-319)
This product is an ELISA kit for the determination of Human Complement C5a in the samples of Plasma and Serum. It is highly sensitive and available for the detection of Human Complement C5a as low as 29 pg/mL.
Summary
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Specifications
| Assay Type |
CLIA (chemiluminescent immunoassay) |
| Sensitivity |
29 pg/mL (78-5000 pg/mL) |
| Pack Size |
96 tests |
| Species Reactivity |
Human |
| Target |
C5a |
| Cross Reactivity |
No significant cross-reactions have been observed between Human Complement C5a and analogues, but existing techniques may limit the detection of cross-reactions with untested analogues. The recombinant proteins is not supported. |
| Applications |
ELISA |
| Storage |
The storage of components varies. Please refer to the instructions for details. |
Information
| Introduction |
Complement C5a is the alpha chain released from cleavage of complement C5 protein, which plays an important role in chemotaxis. C5a is an effective chemoattractant, initiating accumulation of complement and phagocytic cells at sites of infection or recruitment of antigen-presenting cells to lymph nodes. C5a plays a key role in increasing migration and adherence of neutrophils and monocytes to vessel walls. White blood cells are activated by upregulation of integrin avidity, the lipoxygenase pathway and arachidonic acid metabolism. C5a also modulates the balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing the autoimmune response. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
