Mouse Anti-Rat CR3 Monoclonal Antibody (CTJS-138) [PE](Cat#: CTA-906)
This product is a conjugated anti-Rat CR3 Monoclonal antibody (CTJS-138) generated from the Mouse. The antibody can be used for FC.
Summary
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Specifications
| Clonality |
Monoclonal |
| Clone |
CTJS-138 |
| Host Animal |
Mouse |
| Isotype |
IgG1 |
| Immunogen |
Rat spleen cell homogenate with Freund's complete adjuvant |
| Species Reactivity |
Rat |
| Applications |
FC |
| Application Notes |
FC: 10 μL/10^6 cells
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Rat CR3. |
| Purity |
≥95% as determined by SDS-PAGE |
| Conjugation |
PE |
| Format |
Liquid |
| Size |
50 test |
| Storage |
Store in dark at 4°C. Do Not Freeze. |
| Type |
Primary Antibody |
Target
| Target Name |
CR3 |
| Alternative Names |
Complement receptor 3; CR3; Macrophage-1 antigen; integrin αMβ2; macrophage integrin; Mac-1; CD11b/CD18 |
| Gene ID |
25021
309684 |
| UniProt ID |
G3V8L7
B2RYB8 |
Information
| Introduction |
Complement receptor 3, also known as Macrophage-1 antigen, integrin αMβ2 or macrophage integrin or Mac-1, is a a human cell surface receptor consisting of CD11b (integrin αM) and CD18 (integrin β2). It is mainly expressed B and T lymphocytes, polymorphonuclear leukocytes (mostly neutrophils), NK cells, and mononuclear phagocytes like macrophages. CR3 is a pattern recognition receptor, capable of recognizing and binding to many molecules found on the surfaces of invading bacteria. CR3 also recognizes iC3b when bound to the surface of foreign cells. iC3b is generated by proteolysis of C3b and binding to the receptor causes phagocytosis and destruction of the foreign cell opsonized with iC3b. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
