PharmaOnco™ Jurkat-B2M KO Cell Line, Single Clone

Creative Biolabs offers Jurkat-B2M KO cell line which B2M gene was knocked out in Jurkat cells.

Jurkat-B2M KO cell line is a type of Jurkat cell line that has been genetically modified to lack the expression of beta-2 microglobulin (B2M). B2M is a protein that is required for the proper function of major histocompatibility complex (MHC) class I molecules, which are important for antigen presentation to T cells. By knocking out the expression of B2M, the Jurkat-B2M KO cell line can be used to study the role of B2M in antigen presentation and T cell activation. This cell line can be useful for investigating the immune response to viral infections, cancer, and autoimmune diseases, as well as for drug development and testing.

Loss of gene function;
Stability and Specificity;
Reliability and reproducibility;

Functional assay

B2M

Human

Jurkat

The B2M gene, also known as beta-2 microglobulin, is a gene that provides instructions for making a protein that is found on the surface of all cells in the body. This protein is important for the immune system, as it plays a role in presenting antigens to immune cells to help the body identify foreign invaders, such as bacteria or viruses. Mutations in the B2M gene can lead to various health conditions, including certain types of cancer and autoimmune disorders.

1 x 10e6 cells/vial, Frozen

Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.

Identity testing is required for newly established cell lines. Isoenzyme analysis is used to confirm the identity of the species of a cell line. Alternative methods for identity testing include DNA fingerprinting, STR analysis and karyology.

A broad range of viruses is susceptible to affecting human cell lines. We can provide in vivo/vitro virus safety assays by utilizing various animal systems. These viruses include: adventitious viruses, bovine viruses, human and simian viruses, porcine viruses, retrovirus and rodent viruses.

We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.

The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species.

Dry Ice

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C). After thawing, cells should be immediately transferred to the appropriate culture medium and maintained under recommended culture conditions.

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Avoid multiple freeze/thaw cycles

For research use only, not for diagnostic or therapeutic use.

All of our stable cell lines meet the highest quality standards and have been confirmed to be pathogen-free.