CD46 Blocking Peptide-1(Cat#: CTD-145)
This product is a synthetic peptide that used for blocking the activity of human CD46 antibody.
Summary
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Specifications
| Sequence |
TPPPKIKNGK HTFSEVEVFE YLDAVTYSCD PAPGPDPFSL IGESTIYCGD |
| Purity |
>90% |
| Pack Size |
100 μg |
| Format |
Lyophilized |
| Conjugate |
Unconjugated |
| Species Reactivity |
Human |
| Applications |
Blocking; WB |
| Storage |
Short at 4°C for short term and at -20°C for long term. |
Information
| Introduction |
Membrane cofactor protein acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. In microbial infection, a number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. It also acts as a receptor for Adenovirus subgroup B2 and Ad3, a receptor for cultured Measles virus, a receptor for Herpesvirus 6/HHV-6, and a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
