Complement C1QBP Blocking Peptide(Cat#: CTD-009)
This product is a synthetic peptide that used for blocking the activity of human Complement C1QBP antibody.
Summary
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Specifications
| Solubility |
Soluble in Water. |
| Purity |
>90% |
| Pack Size |
100 µg |
| Format |
Lyophilized |
| Conjugate |
Unconjugated |
| Species Reactivity |
Human |
| Applications |
Blocking |
| Storage |
Short at 4°C for short term and at -20°C for long term. |
Information
| Introduction |
C1QBP is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. It acts as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades at the cell surface. It is a putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. It is a high affinity receptor for kininogen-1/HMWK in complex with cytokeratin-1/KRT1. The secreted form of C1qBP may enhance both extrinsic and intrinsic coagulation pathways. It also involves in regulation of antiviral response by inhibiting DDX58- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection; HIV-1 replication, presumably by contributing to splicing of viral RNA; infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B and Staphylococcus aureus protein A; and replication of Rubella virus. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
