LNP023(Cat#: CTI-017)
This product is a potent and selective factor B antagonist, it inhibits factor D with the IC50 of 10 nM.
Summary
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Specifications
| CAS No. |
1644670-37-0 |
| Formula |
C₂₅H₃₀N₂O₄ |
| Molecular Weight |
422.52 |
| SMILES |
O=C(O)C1=CC=C([C@H]2N(CC3=C(OC)C=C(C)C4=C3C=CN4)CC[C@H](OCC)C2)C=C1 |
| IC50 |
IC50: 10 nM |
| Purity |
98% |
| Solubility |
Soluble in DMSO |
| Storage |
Store at -4°C for short term; at -20 °C for long-term storage. |
| Target |
Factor B |
| Introduction |
The factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
