Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-DNMT1 antibody variable domain are respectively connected to the N terminus of the anti-SHH IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can bind two factors simultaneously, block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It is designed for the research of Hormone refractory breast cancer (HRBC) therapy.
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