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DNMT1 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H317 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Tandem Diabody) Human Tandem Diabody DNMT1 Human SHH Human Inquiry
T-BSDB-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem Diabody) Human Tandem Diabody DNMT1 Mouse SHH Mouse Inquiry
SCIGG-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scIgG) Human Single chain IgGs DNMT1 Human SHH Human Inquiry
SCIGG-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scIgG) Human Single chain IgGs DNMT1 Mouse SHH Mouse Inquiry
FVTIG-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scFv4-Ig) Human scFv4-Ig DNMT1 Human SHH Human Inquiry
FVTIG-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv4-Ig) Human scFv4-Ig DNMT1 Mouse SHH Mouse Inquiry
BSSG-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scFv-IgG) Human scFv-IgG DNMT1 Human SHH Human Inquiry
BSSG-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-IgG) Human scFv-IgG DNMT1 Mouse SHH Mouse Inquiry
IGLFV-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv DNMT1 Human SHH Human Inquiry
IGLFV-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv DNMT1 Mouse SHH Mouse Inquiry
BSGV-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (IgG-Fv) Human IgG-Fv DNMT1 Mouse SHH Mouse Inquiry
BSGV-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (IgG-Fv) Human IgG-Fv DNMT1 Mouse SHH Mouse Inquiry
BSDG-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Fv-IgG) Human Fv-IgG DNMT1 Human SHH Human Inquiry
BSDG-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Fv-IgG) Human Fv-IgG DNMT1 Mouse SHH Mouse Inquiry
BABFV-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 DNMT1 Human SHH Human Inquiry
BABFV-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 DNMT1 Mouse SHH Mouse Inquiry
FABVC-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc DNMT1 Human SHH Human Inquiry
FABVC-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc DNMT1 Mouse SHH Mouse Inquiry
SCDBC-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 DNMT1 Human SHH Human Inquiry
SCDBC-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 DNMT1 Mouse SHH Mouse Inquiry
BSDBC-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 DNMT1 Human SHH Human Inquiry
BSDBC-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 DNMT1 Mouse SHH Mouse Inquiry
SCDBF-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc DNMT1 Human SHH Human Inquiry
SCDBF-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc DNMT1 Mouse SHH Mouse Inquiry
BSFVF-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc DNMT1 Human SHH Human Inquiry
BSFVF-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc DNMT1 Mouse SHH Mouse Inquiry
BSDBF-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Diabody-Fc) Human Diabody-Fc DNMT1 Human SHH Human Inquiry
BSDBF-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Diabody-Fc) Human Diabody-Fc DNMT1 Mouse SHH Mouse Inquiry
BSTF-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv DNMT1 Mouse SHH Mouse Inquiry
BSTF-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv DNMT1 Mouse SHH Mouse Inquiry
BSCFV-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scFv-Fc) Human scFv-Fc DNMT1 Mouse SHH Mouse Inquiry
BSCFV-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-Fc) Human scFv-Fc DNMT1 Mouse SHH Mouse Inquiry
MNAB-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Miniantibody) Human Miniantibody DNMT1 Mouse SHH Mouse Inquiry
MNAB-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Miniantibody) Human Miniantibody DNMT1 Mouse SHH Mouse Inquiry
BSFC-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scFv-CH3) Human scFv-CH3 DNMT1 Mouse SHH Mouse Inquiry
BSFC-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-CH3) Human scFv-CH3 DNMT1 Mouse SHH Mouse Inquiry
BSCC-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL DNMT1 Mouse SHH Mouse Inquiry
BSCC-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL DNMT1 Mouse SHH Mouse Inquiry
BIBD-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Bibody) Human Bibody DNMT1 Mouse SHH Mouse Inquiry
BIBD-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Bibody) Human Bibody DNMT1 Mouse SHH Mouse Inquiry
FABFV-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Fab-Fv) Human Fab-Fv DNMT1 Human SHH Human Inquiry
FABFV-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Fab-Fv) Human Fab-Fv DNMT1 Mouse SHH Mouse Inquiry
MiniB-H319 Recombinant Human Anti-DNMT1 x Human Anti-SHH Bispecific Antibody (Minibody) Human Minibody DNMT1 Human SHH Human Inquiry
MiniB-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Minibody) Human Minibody DNMT1 Mouse SHH Mouse Inquiry
SCDB-H317 Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DNMT1 Human SHH Human Inquiry
FABIG-H317 Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Fab-IgG) Human Fab-IgG DNMT1 Human SHH Human Inquiry
TRIB-H319 Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv DNMT1 Human SHH Human Inquiry
BSIG-H317 Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (IgG-IgG) Human IgG-IgG DNMT1 Human SHH Human Inquiry
CROSSAB-H317 Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (CrossMab) Human CrossMab DNMT1 Human SHH Human Inquiry
IGFV-H317 Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (IgG-scFv) Human IgG-scFv DNMT1 Human SHH Human Inquiry
BSDB-H317 Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Diabody) Human Diabody DNMT1 Human SHH Human Inquiry
BSFAB-H317 Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem Fab) Human Tandem Fab DNMT1 Human SHH Human Inquiry
BSFV-H316 Recombinant Human Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem scFv) Human Tandem scFv DNMT1 Human SHH Human Inquiry
SCDB-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DNMT1 Mouse SHH Mouse Inquiry
FABIG-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Fab-IgG) Human Fab-IgG DNMT1 Mouse SHH Mouse Inquiry
TRIB-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv DNMT1 Mouse SHH Mouse Inquiry
BSIG-150 Anti-DNMT1 x Anti-SHH Bispecific Antibody (IgG-IgG) Human IgG-IgG DNMT1 Mouse SHH Mouse Inquiry
CROSSAB-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (CrossMab) Human CrossMab DNMT1 Mouse SHH Mouse Inquiry
IGFV-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (IgG-scFv) Human IgG-scFv DNMT1 Mouse SHH Mouse Inquiry
BSDB-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Diabody) Human Diabody DNMT1 Mouse SHH Mouse Inquiry
BSFAB-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem Fab) Human Tandem Fab DNMT1 Mouse SHH Mouse Inquiry
BSFV-150 Recombinant Anti-DNMT1 x Anti-SHH Bispecific Antibody (Tandem scFv) Human Tandem scFv DNMT1 Mouse SHH Mouse Inquiry

Background

DNMT1 is a highly dynamic enzyme with regulatory properties governing intracellular DNA methylation, which plays the role of the principal DNA methyltransferase in mammalian cells. DNMT1's allosteric sites oversee uphold DNA methylation within cells and de novo DNA synthesis. The structure of the enzyme comprises a smaller catalytic C-terminal region and a sizable regulatory N-terminal region. The ability of DNMT1 is pivotal for the preservation of DNA methylation to ensure the fidelity of epigenetic patterns through cell divisions. However, if methylation patterns get aberrations may cause specific human tumors and developmental abnormalities. DNMT1 emerges as a critical player in maintaining hematopoietic stem cell (HSC) integrity, as HSCs with reduced DNMT1 exhibit impaired self-renewal post-transplantation.

Diverse DNMT-containing complexes and their roles in sustaining DNA methylation illustrated. (Hervouet, et al., 2018) Fig.1 Diverse DNMT-containing complexes and their roles in sustaining DNA methylation illustrated.1

Reference

  1. Hervouet, Eric, et al. "Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma." Clinical epigenetics 10.1 (2018): 1-18.
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