Cobra Venom Factor (CVF) is a non-toxic protein purified from cobra venom. It is a structural analogue of complement component C3 and has the function of complement activation. Treatment with CVF could deplete complement protein and achieve the desired anti-complement effect through continuously activating complement component C3 for a long time. Source:Venom from the Indian cobra naja naja kaouthia purchased from certified serpentariums located in the USA.
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| Application | CVF binds to the victim's factor B and this is then activated by factor D forming CVF,Bb. CVF,Bb is a serine protease specific for the victim's C3 and often C5 as well. Once the complex is generated, it is extremely stable (half-life approximately 7 hours in blood). Then C3 is cleaved to C3b and C3a, C5 is cleaved to C5b and C5a. |
| Composition | Cobra Venom Factor (CVF)in buffer (10 mM sodium phosphate, 145 mM NaCl, pH 7.2). |
| Form | Liquid |
| Concentration | 1.0mg/mL;>300 units/mg;>95% by SDS-PAGE |
| Storage | Storage at -70°C |
It has significantly advanced our research in complement system modulationExcellentThe quality of CVF provided by this supplier is excellent. It has been instrumental in our experiments involving the inhibition of complement activation. Fast shipping and great customer service too.
The product is pure and potent, will definitely reorderExcellentWe tested several CVF suppliers, and this one stood out for its high purity and effectiveness. Our experiments on complement depletion in animal models have never been more precise. Highly recommended!
The product is consistently high-quality, which has been crucial for our reproducibility and accuracy in experimentsExcellentThe CVF arrived in perfect condition and worked exactly as described. It has been an essential component in our studies of complement-mediated cell lysis, providing consistent and reliable results.
This CVF has been critical for our research into complement system dysregulationExcellentWe've been impressed with the purity and potency of this CVF. It's facilitated our research on complement regulation and has proven to be a highly reliable reagent in our experiments.