Creative Biolabs’ overall service will provide our clients with the most comprehensive one-stop complement-related experimental solutions, our service covers cell culture, sample collection, protein purification, functional verification, data analysis and other biological experiment projects.
The multistep cascade of the classical complement pathway (CCP) is initiated and activated by the first component C1 sequence. Binding of C1q to its target results in the stimulation of C1, which in turn activates a downstream multistep cascade in an immunoglobulin-dependent (by binding IgG or IgM) or immunoglobulin-independent manner. C1q does not contain enzymatic activity, but is provided entirely by C1r and C1s. The activativation of the C1 complex will cleave and activate C4, initiating the classical pathway of complement. Here, we briefly summarize the protocol for the hemolytic assay of the C1 complex, which can be used as a screening test and supported by functional analysis data for complement-related studies.
Hemolytic Assay Protocol for C1 Complex
Fig 1. Workflow of hemolytic assay for C1 complex. (Creative Biolabs)
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