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Overview of MCP/CD46
Membrane cofactor protein (MCP/CD46), a cofactor of serine protease factor I, is a widely expressed complement regulatory protein. It is unique among complement proteins, and most cells co-express the four isomers produced by alternative splicing.
Fig.1 Schematic of CD46 protein structure. (Liszewski & Atkinson, 2021)
Membrane Cofactor Protein (MCP/CD46) Purification Protocol
A major problem with the purification of MCP is its tendency to stick nonspecifically to various surfaces, including column matrices and filters. A standard chromatography method to purify MCP is carried out as follows.
Fig.2 Flow chart of membrane cofactor protein (MCP/CD46) purification protocol. (Creative Biolabs)
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Reference
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Liszewski, M.K.; Atkinson, J.P. Membrane cofactor protein (MCP; CD46): deficiency states and pathogen connections. Current Opinion in Immunology. 2021, 72: 126-134.
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