Cancer Cell Engineering Service with β-Catenin Specific Aptamer for Cancer Immunotherapy
Equipped with state-of-the-art instrumentation, Creative Biolabs offers scientific expertise in engineering cancer cells with β-catenin-specific aptamer, providing highly customized services designed to meet our clients' project requirements and timelines.
Introduction of β-Catenin
β-Catenin is a multifunction protein encoded by the CTNNB1 gene in humans. As a protein associated with the cytoplasmic region of E-cadherin, β-catenin has been shown to perform two functions: signal transduction in the Wnt/wg pathway and cell-cell adhesion. Wnt/wg signaling results in β-catenin accumulation and transcriptional activation of specific target genes during development. The cytosolic β-catenin elevates the mutations of Wnt/β-catenin pathway core components in multiple cancer cells, including colon cancer, melanoma, ovarian cancer, hepatocellular carcinoma, endometrial cancer, and prostate cancer.
Clinical Value of β-Catenin in Cancer Therapy
In addition to being considered a potential prognostic biomarker, β-catenin is also an important molecular target in cervical cancer therapy. Besides, nuclear β-catenin expression is related to chemo-resistance and radio-resistance in cervical cancer. There are several approaches for targeting β-catenin that have been developed, including enzyme inhibitors, β-catenin/TCF antagonists, and transcriptional regulators. Some compounds have already progressed to phase II oncology trials, but some are still in the discovery phase. In summary, β-catenin is a potentially druggable target.
Engineering Cancer Cells with β-Catenin-specific Aptamer Service at Creative Biolabs
Previous data have shown that β-catenin can induce transcription and splicing, and can inhibit the transcription of β-catenin target genes. β-catenin-specific RNA aptamer could be a novel tool providing further insight into the potential of nuclear β-catenin for cancer immunotherapy. Since β-catenin is an excellent target for cancer therapeutics, scientists at Creative Biolabs have also paid a lot of attention to it.
Creative Biolabs has accumulated rich experience in the screening of stable aptamer transfectants, our scientists are proficient at selecting high-affinity β-catenin–specific RNA aptamers and engineering cancer cells with RNA aptamers. To assess the effect of the RNA aptamers, RNA coimmunoprecipitation assay, soft agar colony formation assay, and cell proliferation assay will be performed. From project design to effect assessment, our team will develop a complete solution for our clients’ needs.
Creative Biolabs combines deep, industry-leading expertise in Cancer Cell Engineering with innovative platforms to support any phase of our clients’ projects. We are glad to serve our global clients with professionalism and expertise in this field. If you are interested in our high-quality service of engineering cancer cells with β-catenin-specific aptamer, please feel free to contact us or directly send us an inquiry.
Download our brochure