T cells can express tumor-antigen by CAR design construction construction, which can lead to a high rate of complete response in patients with hematologic malignancies. Despite its early success, CAR-T cells still face challenges associated with treatment-related toxicity and tumor antigen negative recurrence due to their wide applications in cancer treatment to a larget extent. Creative Biolabs has overcome these difficulties by programming gene modules and improved the therapeutic efficacy and specificity of T cells.
Program CAR design to meet the needs of most customers, with high specificity, it can be easily produced in a mature way against most antigens and can be grafted into a car design easily by our experienced scientific team.
It is a strategy to control the severe toxicity of CAR-T cells by rapidly ablating the transplanted cells with a suicide switch.
Fig.1 Management of
chimeric antigen receptor (CAR) T-cell toxicity
Easily provide bispecific CAR to alleviate this escape mechanism by targeting both antigens simultaneously.
Through blocking scFv and controlling T cell status, they can be promoted to reach the tumor microenvironment easily.
Control normoxia or hypoxic conditions to regulate CAR degradation or stable expression.
Programming CAR-T design improves cell persistence and overcomes immunosuppression, emphasizing the control of CAR-T specificity and activity.
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