How We Achieve Targeting Delivery
Fig 6. Nanoparticle platform for drug delivery.
Targeting modules enable precise addressing of pathological entities across tissue, cellular, and microbial scales. These bioaffinity agents are integral to precision delivery platforms and molecular imaging diagnostics. With over a decade of expertise
in protein engineering and peptide optimization, Creative Biolabs develops tailored conjugation architectures for diverse biomedical applications. Our cutting-edge bioengineering infrastructure supports comprehensive molecular
homing solutions for oncological therapeutics and diagnostic innovations. Partnering with researchers, we provide end-to-end strategic guidance throughout the innovation pipeline—translating conceptual frameworks into validated
clinical-stage biotherapeutics.
Targeted drug delivery enhances therapeutic agent accumulation at disease sites through engineered transport mechanisms. Our targeting module can bind to the target through receptor-ligand binding, thereby delivering drugs to specific locations. Here
is the comment targeting module we provide.
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Peptides
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Peptides represent biopolymeric structures formed through covalent amide linkages between amino acid residues. As targeting modules, these biomolecules, including cell-penetrating peptides (CPPs), homing peptides (HPs), etc.,
have emerged as promising pharmacotherapeutics due to their enhanced conformational versatility relative to antibody-based treatments.
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Antibodies
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Antibodies achieve antigen-specific binding through variable fragment regions, either neutralizing pathogenic cascades or orchestrating macrophage-mediated opsonization of pathological entities. Antibodies now constitute frontline biopharmaceutical interventions
in clinical oncology and immune disorder management.
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Aptamers
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Aptamers are used as targeting modules in targeted drug delivery due to their high specificity and ability to bind to specific targets with high affinity. They can be conjugated to module delivery systems, enabling selective delivery to cells or tissues
expressing the aptamer's target. It mainly includes the nucleic acid aptamer and peptide aptamer.
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Functionalized Lipid
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Functionalized lipids have emerged as a promising targeting module for targeted delivery in various biomedical applications. These lipids are designed to possess specific biological functions or interactions, allowing them to selectively bind to and accumulate
in specific cells, tissues, or organs. It includes DSPE-PEG-Folate，DSPE-PEG-Biotin，DSPE-PEG-COOH, etc..
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Targeted Polymer
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Targeted polymers have emerged as a promising class of materials for targeted delivery of therapeutics, diagnostics, and imaging agents. They are designed to accumulate selectively in specific cells or tissues, reducing side effects and enhancing efficacy.
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Responsive Materials
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Responsive materials, also known as smart materials, are designed to change their properties in response to specific stimuli, enabling targeted drug delivery and release. These materials can be responsive to a variety of stimuli, including temperature,
pH, light, ROS, glucose and magnetic fields.
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A number of model candidates that are highly potent and have low therapeutic indications can be targeted to the required diseased site using the appropriate delivery system. For instance, some drugs encapsulated in liposomes can have a significantly altered
pharmacokinetics. Creative Biolabs has pioneered the development of advanced delivery strategies, including liposomes, LNPs (with a focus on liposomes and LNPs), lipid-polymer hybrid nanoparticles, exosomes, virus-like particles
(VLPs), Fc fusion proteins, albumin, and more.
Liposomes constitute sophisticated drug delivery platforms, structured as nanoscale vesicles with amphiphilic phospholipid membranes. These systems enable temporally and spatially regulated therapeutic payload release,
enhancing bioavailability through physiological synchronization during treatment while facilitating site-specific biodistribution to designated cellular or anatomical sites.
Lipid nanoparticles (LNPs) are precision-engineered for tissue-specific biodistribution through advanced molecular architecture. Their proprietary bilayer configuration enables optimized cellular internalization and intracellular
payload release via endosomal bypass. This organotropic delivery paradigm demonstrates clinical potential across oncology, inherited metabolic pathologies, and infectious agent management. By compartmentalizing therapeutic
cargo within LNPs, researchers achieve enhanced pharmacodynamic profiles with minimized off-target effects, positioning these nanovehicles as transformative tools in next-generation biotherapeutics.
⭐ Lipid-Polymer Hybrid Nanoparticle
Lipid-polymer hybrid nanoparticles (LPHNPs) are core-shell architectures merging lipid and polymer matrices, harnessing synergistic advantages of both vesicular and polymeric nanovectors. These systems enable superior payload
retention, temporal release modulation, extended systemic persistence, and programmable biodirectionality—positioning them as transformative platforms across oncology, nucleic acid transport, and next-generation
immunization strategies.
Exosomes—naturally occurring endogenous nanovesicles—are emerging as novel therapeutic platforms owing to their intrinsic tropism for molecularly defined cellular niches. By encasing pharmacological payloads
within lipid bilayer membranes, these vesicles achieve directional cargo transfer to pathological loci, maximizing therapeutic indices while minimizing systemic toxicity. Their inherent biosafety profile and natural
degradability further position them as preferred biocarriers for precision medicine applications.
Virus-Like Particles (VLPs) are non-pathogenic nanostructures derived from viral capsid components, functioning as versatile carriers for site-specific therapeutic payload delivery. These particles can be engineered via
surface functionalization to direct cargo to designated cellular or anatomical regions, amplifying treatment precision while curtailing off-target effects.
⭐ Fc Fusion Protein
Fc fusion proteins represent bioengineered constructs that integrate the immunoglobulin-derived Fc segment with therapeutic payloads, augmenting delivery efficiency and pharmacodynamic performance. The Fc region—a
conserved antibody component—is strategically utilized for its Fc receptor binding capacity on immune effector cells, extending circulatory persistence of the conjugated biomolecule and enabling directional transport
to pathological sites.
⭐ Albumin
Albumin emerges as a transformative therapeutic carrier, leveraging its status as the body's primary circulatory transporter of nutrients via polyvalent binding domains and extended plasma persistence. Rational conjugation
strategies involve covalently linking biologics to this endogenous protein through site-specific bioconjugation at its amino- or carboxyl-terminal regions, capitalizing on albumin's structural versatility to enhance
drug stability and systemic retention.
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Conventional Drug Delivery
Targeted Drug Delivery
Fig.1 Scheme of drug loading options in targeted drug delivery.1 
