In the pursuit of precision medicine, the demand for highly specific and versatile molecular tools is greater than ever. Aptamers are revolutionizing this landscape. As synthetic nucleic acid or peptide ligands, they offer unparalleled specificity and the robust stability needed to overcome the limitations of traditional biomolecules. At Creative Biolabs, we empower this revolution with a comprehensive portfolio of aptamer products, meticulously designed to provide the innovative solutions required for advanced research in targeted drug delivery and beyond.
Overview
Aptamers are short, synthetic single-stranded oligonucleotides (DNA or RNA) or peptides that function with high specificity and affinity to bind targets, earning them the popular moniker 'chemical antibodies.' Their development through an in vitro selection process known as systematic evolution of ligands by exponential enrichment (SELEX) allows for precise engineering, circumventing many limitations associated with biological production methods. Aptamers, therefore, have a number of advantages over traditional antibodies, such as better batch-to-batch uniformity and low immunogenicity. These attributes, combined with their small molecular size and the ease of large-scale chemical synthesis, have established them as indispensable assets in the fields of targeted drug delivery, advanced diagnostics, and therapeutic development.
High Specificity & Affinity
Aptamers can be engineered to bind to a vast range of targets, including proteins, small molecules, and even whole cells, with binding constants comparable to antibodies.
Rapid Discovery Cycle
The in vitro nature of the SELEX process enables a significantly faster screening and development cycle, accelerating the discovery of novel aptamers for new applications.
Chemical Synthesis
Unlike biological antibodies, aptamers are chemically synthesized, ensuring high purity, consistency, and easy modification with functional groups or labels.
Cost-Effective & Scalable Production
Chemical synthesis enables aptamers to be produced at a lower cost per batch and easily scaled for large-volume commercial demands.
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Our aptamer products for different targets are available in unlabeled, biotinylated, or FITC-labeled formats.
DNA Aptamers
Our DNA aptamers are single-stranded nucleic acid molecules specifically designed to bind with high precision to targets. With their outstanding stability and minimal immunogenicity, they are perfectly suited for a diverse array of diagnostic and research applications.
RNA Aptamers
RNA aptamers provide a powerful tool for targeting proteins and other molecules with high affinity and specificity. They are particularly useful for applications where a flexible, three-dimensional structure is required for optimal binding.
Peptide Aptamers
Peptide aptamers are short constrained peptide sequences expressed within a stable protein scaffold. They are highly versatile and are often used for intracellular targeting and modulation of protein-protein interactions.
Beyond our standard aptamer products, we supply a suite of specialized targeting modules to facilitate your research. Our catalog features fluorescently-labeled aptamers, adapter screening kits, as well as peptides, functionalized lipids, and targeted polymers for a variety of delivery applications.
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At Creative Biolabs, we offer a range of specialized services to support you at every stage of your aptamer-based research.
Custom Aptamer Development Services
Utilize our proprietary SELEX platform to discover and optimize novel aptamers for your specific target of interest.
Aptamer Conjugation
Expert conjugation of aptamers with a variety of payloads, including small molecule drugs and nanoparticles, to create aptamer-drug conjugates and other advanced delivery systems.
Adapter-based High-Throughput Sequencing
Leverage next-generation sequencing to efficiently screen aptamer libraries, accelerating the discovery and selection process.
Fluorescent Labeling
Custom labeling of aptamers with fluorescent dyes for diagnostics, cell imaging, and flow cytometry applications.
Process Optimization
Scaling up aptamer synthesis and purification to meet the demands of preclinical development.
Applications of Aptamers
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Therapeutic & Drug Delivery: Aptamers can act as therapeutic agents or serve as targeting moieties in drug delivery systems (e.g., Aptamer-drug conjugates, aptamer-functionalized Lipid Nanoparticles) to precisely treat diseases like cancer, viral infections, and inflammatory disorders.
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Diagnostic & Rapid Detection: Leverage the high specificity of aptamers in diagnostic assays and biosensors for the rapid and targeted detection of various components, including metal ions, antibiotics, pesticide residues, mycotoxins, proteins, microorganisms, and cells.
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Cellular Imaging: Use fluorescently-labeled aptamers to visualize and track specific cell types or surface markers in real-time, providing valuable insights into cellular processes and disease states.
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Biomarker Discovery: Utilize the high specificity and affinity of aptamers to identify and isolate novel disease biomarkers from complex biological samples, accelerating research and development.
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Antiviral & Antibacterial Agents: Develop aptamers that directly bind to and inhibit the function of viral or bacterial components, acting as potent antimicrobial agents.
Why Choose Creative Biolabs?
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Quality and Consistency: Our products are manufactured with rigorous quality control standards, ensuring high purity, superior batch-to-batch consistency, and reliable performance in your experiments.
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Proprietary SELEX Technology: Our mature, state-of-the-art SELEX platform ensures the rapid and successful discovery of high-affinity aptamers for even the most challenging targets.
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Extensive Aptamer Portfolio: We offer a diverse selection of DNA, RNA, and peptide aptamers, available with a wide range of fluorescent dyes (e.g., FITC) and other labels, providing the perfect starting point for your research.
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Customization and Conjugation Expertise: Beyond our catalog, we specialize in custom aptamer development and bespoke conjugation strategies, enabling you to create unique, multi-functional delivery systems.
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Comprehensive R&D Partnership: From initial concept to final validation, our team of experts provides end-to-end technical support, ensuring you have a collaborative partner to guide your aptamer research every step of the way.
Product Ordering Process
FAQs
What are the key differences between aptamers and antibodies?
Aptamers are nucleic acids or peptides, while antibodies are proteins. Aptamers are chemically synthesized, ensuring high purity and low batch-to-batch variation, whereas antibodies are produced biologically. Aptamers also offer superior thermal stability and can be easily modified, making them highly versatile.
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Item
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Aptamers
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Antibodies
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Substance
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Nucleic Acid
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Protein
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Size
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20K
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150K
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Specificity
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Strong
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Strong
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Affinity
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High
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High
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Target Types
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Diverse
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Limited
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Screening Time
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Short
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Long
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Performance Stability
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Consistent
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Varies by batch
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Storage Stability
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Very Stable
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Unstable
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Molecular Modification
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Very Convenient, Controllable
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Limited, Uncontrollable
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Production Method
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Chemical Synthesis
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Animal/In Vitro Cultivation
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Can Creative Biolabs develop an aptamer for my specific target?
Yes. Our custom aptamer development service is specifically designed for this purpose. We use our advanced SELEX technology to identify and optimize aptamers that bind with high affinity and specificity to your unique molecular target.
What is the SELEX process?
SELEX is a powerful iterative process used to discover aptamers. It involves screening a large random library of nucleic acid sequences against a target molecule. The process repeatedly selects for sequences that bind to the target, amplifying them and enriching the pool until highly specific aptamers are isolated.
How can aptamers be used for targeted drug delivery?
Aptamers can be conjugated to various delivery systems, such as lipid nanoparticles or polymeric carriers. The aptamer acts as a "zip code," directing the entire system and its therapeutic payload to a specific cell type or tissue, thereby minimizing off-target effects and increasing therapeutic efficacy.
For Research Use Only.
