Creative Biolabs provides reliable, large-scale manufacturing of targeted delivery systems under strict quality control, ensuring consistency for your programs.
We are living in a new era of medicine, powered by the incredible promise of nucleic acid therapeutics—from life-saving mRNA vaccines to the precision of CRISPR gene editing. But for every groundbreaking discovery, there's a monumental hurdle: how to
deliver these delicate, powerful instructions safely to their exact destination within the body. This is the story of Lipid Nanoparticles (LNPs)—the ingenious vehicles that turned this scientific dream into a reality. Yet, as any pioneer
knows, the first breakthrough is just the beginning. The true challenge lies in the intricate journey of transforming that initial success into a reliable, scalable, and clinical-ready therapy. At Creative Biolabs,
we specialize in overcoming these intricate barriers, leveraging decades of expertise to provide end-to-end LNP development services designed to accelerate your research and empower your breakthroughs.
What Are Lipid Nanoparticles (LNPs)?
At the core of our platform is a precisely engineered delivery system: the LNP. Each LNP is a sophisticated nano-vehicle, constructed from a defined blend of ionizable lipids, cholesterol, helper lipids, and PEG lipids. This specific architecture is purpose-built
to overcome a fundamental challenge: protecting delicate nucleic acid payloads from degradation in the bloodstream and ensuring their functional delivery to target cells. It is this robust and reproducible capability that has established
LNPs as the undisputed gold standard in non-viral nucleic acid delivery. Their pivotal role in the efficacy of groundbreaking mRNA vaccines serves as definitive, real-world validation of this technology's power.
Efficient Transfection
Reduced Immunogenicity
Enhanced Stability
Targeted Delivery
Four Core Components
An LNP is not a simple fat droplet. It is a carefully engineered particle composed of four key lipid components, each with a specific function:
Ionizable Lipids
The intelligent core of the LNP. Their smart, pH-responsive charge enables them to encapsulate genetic payloads and release them precisely inside target cells.
Helper Lipids
Acting as structural bricks, they provide essential reinforcement to the LNP's framework, ensuring the particle remains stable and intact within the bloodstream.
PEG Lipids
They create a protective, water-loving "cloud" around the LNP. This stealth shield helps it evade the immune system, extending its time to find the target.
Cholesterol
More than just a filler, it's a crucial stabilizer. It enhances the particle's structural integrity and promotes efficient fusion with the cell membrane.
One-Stop Solution for LNP Development
Learn More about LNP Development Services
Creative Biolabs provides a complete spectrum of services, from initial design to final characterization, ensuring a seamless and efficient development process.
mRNA Synthesis & Modification
Our bioinformatics team collaborates with you to design and optimize mRNA sequences for your specific application, ensuring high expression levels and robust performance.
In Vitro Transcription (IVT)
We use a scalable, cell-free process to synthesize high yields of mRNA from a linearized DNA template.
100 bp - 20,000 bp
0.1 mg – 1 g
Capping & Modification
We provide expert capping and modification services to enhance the performance and stability of your mRNA.
Uncapped, Cap0, Cap1
N1-Me-Ψ, 5moU, etc
Purification
Our multi-step purification process effectively removes unwanted impurities, such as dsRNA and template DNA, which can trigger off-target immune responses.
Quality Control (QC)
Every batch undergoes rigorous QC analysis to confirm its quality.
Appearance
Concentration
Purity
Endotoxin
LNP Preparation & Formulation
Our expertise covers the entire LNP formulation process, from the initial selection of lipids to final encapsulation. Using advanced microfluidic mixing techniques, we achieve precise control over critical quality attributes such as particle size, polydispersity,
and encapsulation efficiency (EE).
Payload Encapsulation
We offer custom formulations tailored to encapsulate a wide range of payloads, including mRNA, siRNA, DNA plasmids, and small molecules.
Fluorescently Labeled LNPs
For researchers needing to visualize and track LNP delivery, we offer LNPs with incorporated fluorescent lipids or dyes (e.g., DiD, DiI) to enable real-time in vitro and in vivo tracking and cellular
uptake studies.
Active Targeting LNP Development
We engineer next-generation LNPs with active targeting ligands (peptides, antibodies, or aptamers) to dramatically improve delivery specificity and therapeutic efficacy while minimizing off-target effects.
High-Throughput LNP Screening
Our automated, high-throughput screening platform rapidly identifies optimal LNP formulations for your specific payload and application, that deliver desired characteristics such as target particle size, low polydispersity index (PDI), and high EE. By
leveraging a Design of Experiments (DoE) approach, we can screen hundreds of different lipid combinations, molar ratios, and process parameters in a single run, generating a robust data set in a fraction of the time required
by traditional methods.
LNP Characterization
We offer a comprehensive suite of analytical services to validate the quality and performance of your LNPs. Our advanced techniques ensure every batch meets the highest standards for:
Item
Description
Testing Method
Standard
Appearance
A simple but critical check for gross contamination or aggregation.
Visual observation
No foreign objects
Particle Size & PDI
Ensures a uniform particle size distribution for consistent biological performance.
The core development phase, where we design and formulate a custom LNP system optimized for your payload.
Customer-provided or synthesized by us
LNP
2-4 Weeks
Characterization
The quality assurance phase, where we analyze the physical and chemical properties of the LNP to ensure it meets all specifications.
Comprehensive QC Report
1-2 Weeks
In Vivo Testing
(Optional)
An optional phase to evaluate the in vivo performance, biodistribution, and efficacy of the LNP system.
Biodistribution & Efficacy Report
Variable
Applications of LNP Delivery in Modern Research
The versatility of LNP technology opens up new possibilities across a broad range of scientific disciplines. Our services are designed to help you harness this potential to accelerate your work in:
Gene Therapy: Delivering corrective genes or gene-editing components (e.g., CRISPR-Cas9) with high precision to treat genetic disorders.
Oncology: Enabling targeted delivery of therapeutics to tumor cells, reducing systemic toxicity, and improving treatment outcomes.
Vaccinology: Rapidly developing highly effective mRNA vaccines for infectious diseases and cancer.
Immunology: Modulating immune responses with targeted delivery of immunomodulatory payloads to specific immune cells.
Precision Medicine: Creating custom-tailored therapies that are more effective and have fewer side effects.
Why Partner with Creative Biolabs?
Get a Custom Quote
At Creative Biolabs, we offer more than just a service; we provide a collaborative partnership built on expertise, innovation, and unwavering support.
End-to-End Solutions
We offer a seamless, one-stop service that guides you from concept to validated product, eliminating the need for multiple vendors.
Innovative, Modular Platform
Our unique approach combines versatile Module Delivery Systems with a powerful toolkit of Targeted Modules, providing unparalleled customization and control.
Unrivaled Scientific Expertise
Our team of specialists possesses decades of experience in drug delivery, LNP technology, and payload engineering.
Scalability & Quality
We ensure consistent quality from research-grade to GMP-like production, offering a de-risked solution that scales with your needs.
Collaborative Partnership
We act as an extension of your team, providing expert consultation and transparent communication at every step.
By partnering with us, you gain a dedicated team that is invested in your scientific vision, helping you navigate complex challenges and accelerate your path to discovery.
Kits containing all necessary lipids and buffers for in-house LNP preparation.
Inquiry
FAQs
What types of payloads can you encapsulate in LNPs?
We can encapsulate a vast array of payloads, including all forms of nucleic acids (mRNA, siRNA, DNA), small molecule drugs, peptides, and proteins. Our modular platform allows for precise customization based on your specific payload's properties.
What is the typical turnaround time for a custom LNP project?
The timeline varies depending on the project's complexity, from initial formulation to full characterization. However, our streamlined workflow and advanced technology are designed to provide a rapid, efficient process, with most projects completed within
4-8 weeks from project initiation.
How do you ensure the quality and stability of your LNPs?
Our commitment to excellence is reflected in our robust quality assurance system. Using state-of-the-art techniques such as DLS, zeta potential, and HPLC, we ensure every LNP we produce delivers optimal performance in size distribution, PDI, encapsulation
efficiency, and long-term stability.
Can you help with the design of my therapeutic payload?
Absolutely. We offer comprehensive services for nucleic acid synthesis and modification, and our team of specialists can provide expert consultation to optimize your payload's design for enhanced stability and expression.
What makes Creative Biolabs' LNP platform "modular"?
Our modular platform allows us to combine distinct components—such as different lipid mixes, targeted ligands, and responsive materials—to create a bespoke LNP system tailored to your specific application. This flexibility enables us to tackle a wide
range of drug delivery challenges with precision and efficiency.
Our services are For Research Use Only. We do not provide services to individuals.
