Transforming a groundbreaking molecule into a life-changing therapy is a complex journey, often hindered by delivery challenges such as solubility, stability, and targeting precision. We understand these frustrations because our mission is to solve them. At Creative Biolabs, we believe the future of effective therapeutics lies in smarter delivery, and that future is built on functionalized lipids. Our curated portfolio of these advanced molecules provides you with the foundational tools to engineer delivery systems that work in harmony with the body. These systems are designed to actively protect your valuable therapeutic agents, navigate the biological environment with precision, and ensure they reach their intended destination.
Overview
The engineering of functionalized lipids constitutes a critical paradigm shift in targeted drug delivery, providing the fundamental chemistry for the fabrication of sophisticated nanocarriers, including liposomes and lipid nanoparticles (LNPs). The site-specific incorporation of functional moieties onto either the headgroup or acyl chain of a lipid molecule allows for the precise modulation of the nanocarrier's biodistribution and biological fate. Empirical evidence from the literature robustly supports the capacity of these modified lipids to augment colloidal stability, extend plasma half-life, and confer cell-targeting specificity. This is accomplished through the rational design of lipid molecular structure, which governs its pharmacokinetic and pharmacodynamic profiles. A prime example is the PEGylation of lipid headgroups, which generates a hydrophilic corona that sterically hinders opsonization and subsequent clearance by the mononuclear phagocyte system (MPS), thereby promoting prolonged systemic circulation. Concurrently, the functionalization of the lipid surface with high-affinity ligands (e.g., monoclonal antibodies, peptides, aptamers) enables active targeting. This mechanism ensures selective binding and receptor-mediated endocytosis into specific cell populations, a prerequisite for achieving high signal-to-noise ratios in diagnostic imaging and for maximizing therapeutic efficacy while minimizing off-target effects.
Enhanced Biodistribution
Allows for the modulation of a nanocarrier's journey through the body, increasing its concentration at the target site while reducing accumulation in healthy tissues.
Controlled Release
Provides a mechanism for on-demand payload release in response to internal or external stimuli, such as changes in pH or temperature within a tumor microenvironment.
Active Targeting
Enables specific binding to cells of interest through conjugated ligands, leading to higher therapeutic efficacy and reduced off-target effects.
Multi-modal Functionality
Functionalized lipids can be combined within a single nanocarrier to achieve multiple goals, such as simultaneous targeting, imaging, and controlled release.
Explore Our Product Portfolio
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Discover the perfect functionalized lipids product for your research.
Ligand Conjugated Lipids
These lipids are pre-functionalized with targeting ligands to facilitate active, cell-specific delivery. They are essential for advanced drug delivery systems requiring targeted cellular recognition and uptake.
Ionizable Lipids
The core component of modern LNP components, ionizable lipids enable high-efficiency encapsulation of negatively charged payloads like mRNA and siRNA, while facilitating endosomal escape for robust intracellular delivery.
Stimuli-Responsive Lipids
Engineered to release their payload in response to specific triggers such as pH, temperature, or light, these lipids offer a new level of control for spatial and temporal delivery in complex biological environments.
Fluorescent Lipids
Our fluorescently labeled lipids are perfect for real-time tracking, in vitro cell visualization, and diagnostic applications, allowing you to monitor nanocarrier uptake and biodistribution with ease.
PEG Derivatives
These PEGylated lipids improve the stability and circulation time of your nanocarriers, providing a "stealth" effect that helps your delivery system evade immune detection and reach its target more effectively.
Other Functional Lipids
Explore our custom-synthesis capabilities for a wide range of specialized lipids, including novel headgroups, unique fatty acid chains, or other functional groups to meet your most specific research needs.
For researchers building advanced targeted delivery systems, we also provide related products like peptides, aptamers, and targeted polymers to complement our lipid offerings and facilitate the development of fully integrated module delivery systems such as liposomes and LNPs.
Need a Custom Solution?
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For researchers specifically focused on targeted delivery, our expertise extends to every stage of their development. Our goal is to provide the high-quality, professional support you need to turn your innovative therapies into reality.
Custom Lipid Synthesis
We provide end-to-end custom synthesis services for novel lipid structures, ensuring your product meets specific purity requirements (90%, 95%, 98%, etc.).
Scale-Up Production
Our production capabilities range from small-scale quantities at the mg level to large-scale, kilogram-level production, supporting your project from initial R&D to preclinical stages.
Drug-Lipid Conjugate
Our experts can develop stable covalent links between your drug payload and a lipid, enabling new formulations and controlled release strategies.
Custom Module Delivery Systems
We offer full-service development and optimization of delivery systems, from initial formulation design of liposomes or LNPs to large-scale production.
Case Study
DSPE-PEG-Cyanine 5 (Cy5)
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MW: 2000 Da
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Excitation/Emission: 650/670nm
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Purity: >90%
DSPE-PEG-Cyanine 5.5 (Cy5.5)
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MW: 2000 Da
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Excitation/Emission: 675/700nm
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Purity: >90%
Applications of Functionalized Lipids
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Gene Therapy & Nucleic Acid Delivery: Ionizable lipids and PEG derivatives are essential for formulating stable LNPs to efficiently deliver mRNA, siRNA, and RNA-guided gene editing systems for gene therapy.
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Oncology: Use ligand conjugated lipids for targeted chemotherapy to minimize side effects, or stimuli-responsive lipids for payload release in the acidic tumor microenvironment.
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Imaging & Diagnostics: Enhance imaging resolution and sensitivity by using Fluorescent Lipids for real-time tracking or Ligand Conjugated Lipids to target disease-specific biomarkers.
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Neuroscience & Ocular Therapeutics: Ligand conjugated lipids and stimuli-responsive lipids are key to overcoming biological barriers like the Blood-brain barrier (BBB) for targeted delivery of therapeutics in neuroscience and ocular fields.
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Infectious & Autoimmune Diseases: Ionizable lipids are used for developing stable vaccines and therapies for infectious diseases. For autoimmune disorders, Ligand conjugated lipids deliver anti-inflammatory agents to specific immune cells, reducing systemic side effects.
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Cosmetics & Dermatology: F In dermatology, functional lipids enhance the delivery of active ingredients in topical formulations, improving their efficacy and stability within the skin.
Why Choose Creative Biolabs?
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Rapid Custom Synthesis: Our extensive inventory of high-quality raw materials ensures a streamlined and efficient synthesis process. This allows us to rapidly produce a wide range of standard and custom lipids, minimizing lead times and accelerating your research timeline.
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Uncompromising Quality and Purity: Our lipids are synthesized and purified to meet stringent quality standards, with customizable purity levels to fit your specific research and regulatory requirements. Every product is accompanied by a certificate of analysis (COA) to ensure transparency and confidence.
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Integrated Product and Service Portfolio: Our seamless integration of a diverse product catalog with custom synthesis and analytical services means you have a single, reliable partner for all your nanocarrier development needs.
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Scale and Flexibility: Our production capabilities are designed to grow with your project. We offer seamless scale-up from milligram-scale R&D quantities to kilogram-scale production for preclinical research, ensuring a consistent and reliable supply chain.
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Deep Scientific Expertise: Our team of experienced lipid chemists and nanocarrier specialists is here to collaborate with you. From advising on the best functional lipid for your application to designing a custom synthesis or conjugation strategy, we provide the scientific partnership you need to succeed.
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Dedicated Technical Support: Our team of PhD-level scientists is available to provide expert guidance, from product selection to troubleshooting complex formulation challenges, ensuring your project stays on track.
Product Ordering Process
FAQs
What types of ligand-conjugated lipids does Creative Biolabs offer?
We offer a wide range of ligand-conjugated lipids based on common lipid backbones like DSPE, DOPE, DMPE, DPPE, and DMG. These are pre-functionalized with various ligands to facilitate active targeting to specific cells or tissues. Our portfolio includes products for common targets, but we also specialize in synthesizing custom conjugates to match your unique research requirements.
Why are functionalized lipids critical for targeted drug delivery?
Functionalized lipids are the building blocks that add "intelligence" to a delivery system. By modifying lipids with specific chemical groups, we can control how the nanocarrier interacts with its environment, enabling capabilities like active targeting, on-demand release, and improved stability—all of which are essential for effective and safe therapeutic delivery.
What is the benefit of using pre-conjugated lipids for my research?
Using pre-conjugated lipids saves significant time and resources compared to performing the conjugation yourself. Our products are rigorously purified and characterized, ensuring consistent, high-quality results. This allows you to focus on the biological application of your research rather than the complex lipid chemistry.
Can Creative Biolabs assist with formulating liposomes or LNPs using your products?
Yes, our custom module delivery systems service is designed for exactly this purpose. Whether you need help with formulation design, process optimization, or full-scale development, our team of experts can partner with you to create a high-performance system for your unique payload and application.
What are the key considerations when choosing a functionalized lipid for my application?
When selecting a functionalized lipid, several factors are crucial: the type of payload (e.g., mRNA, protein, small molecule), the desired target cell or tissue, the required release mechanism (e.g., pH-sensitive, temperature-sensitive), and the necessary purity level for your research stage. Our team can assist you in navigating these choices to find the optimal solution.
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