Complement receptor type 1
(CR1), also known as CD35, is a 210-290 kDa membrane-bound glycoprotein with specificity for C3b and C4b. CR1 is a
key factor in the activation of the plasma protein complement system. CR1 shares structural similarities
with various proteins, such as factor H, decay accelerating factor (DAF), IL-2 receptor and β2-glycoprotein 1, many
of which act as key regulators of complement activity. CR1 is a multifunctional protein that is present in different
cells, such as monocytes, macrophages and dendritic cells. On neutrophils and monocytes, it is intimately associated
with the adhesion of C4b/C3b-binding ligands. CR1 on B lymphocytes plays a crucial role in promoting antigen
presentation to T cells. In addition, CR1 is involved in various diseases. In recent years, CR1 has gradually
emerged as an attractive molecule for gaining insight into the pathology, diagnosis and treatment of many diseases.
At Creative Biolabs, our high-quality complement
products as well as customized complement services contribute to the advancement of your complement program.
CR1 Purification Protocol
Although erythrocytes have a low level of CR1 expression, they remind a good choice to obtain CR1 due to their
availability and relatively easy preparation of membrane extracts. Here we describe a simple procedure for the
purification of CR1 from erythrocytes.
Fig.1 Flow chart of CR1
purification protocol. (Creative Biolabs)
To meet the increasing demands of complement research, Creative Biolabs has developed a series of complement
products and analysis service platforms. With advanced technology and an experienced professional team, we provide
cost-effective complement research services to global customers and help you make breakthroughs in the field of
complement research.
Featured Products
All of our complement products have undergone strict quality testing to ensure good experimental results.
Fig.2 Product categories. (Creative Biolabs)
In addition to comprehensive complement products, a variety of featured services are also available at
Creative Biolabs. Our complement services include but are not limited to complement function test, genetic test
and autoantibody test, which provide a promising tool for the monitoring of complement-associated diseases.
Fig.1 Flow chart of CR1
purification protocol. (Creative Biolabs)
