Complement receptors (CRs) are closely related to innate immunity and also play a crucial role in initiating
adaptive immune responses. CR1 is a multifunctional receptor with a high affinity for various complement components,
such as C1q, C3, C4 and mannose-binding lectin. The interaction of CR1 with ligands plays a role in the regulation
of lymphocyte activity. In addition, CR1 occupies an important position in the presentation of antigens to B cells.
Notably, in addition to membrane-bound CR1, leukocytes also release a soluble form of CR1, which acts as an
inhibitor of both the classical and alternative pathways of complement activation. Most
importantly, CR1 has decay-accelerating activity against C3/C5 convertase and acts as a cofactor for factor
I-mediated cleavage of C3b. As a senior expert in the field of complement research, Creative
Biolabs has established a comprehensive complement detection platform.
CR1 Functional Assay Protocol
Here, we are willing to share a simple workflow for the functional characterization of CR1.
Fig.1 Flow chart of CR1 functional
assay. (Creative Biolabs)
As a leading service provider focused on complement research, Creative Biolabs has been delivering
a broad range of complement products and services backed by our
state-of-the-art technology platform and extensive experience for more than a decade. We succeed in meeting your
needs for efficient and cost-effective products and services with excellence and confidence. Creative Biolabs
provides comprehensive complement analysis services to best understand complement components of interest. We provide
tailored solutions for complement analysis to support the specific requirements of research in drug discovery and
disease diagnosis.
Products Available at Creative Biolabs
In addition, our diverse complement products provide the most suitable match for your different research needs.
Fig.1 Flow chart of CR1 functional
assay. (Creative Biolabs)
