The complement decay-accelerating factor, also named CD55 or DAF, is a membrane protein encoded by the CD55 gene in humans. In general, DAF can be detected among hematopoietic and non-hematopoietic cells. Studies have shown that DAF presents important roles in the regulation of the complement system on the cell surface. It recognizes C4b produced during C4 (classical or lectin pathway) activation and C3b fragment produced during C3 (alternative pathway) activation. The interaction of DAF with C4b prevents the formation of the C4b2a C3 convertase, while the interaction with C3b prevents the formation of C3bBb C3 convertase. New research shows that the functional site of DAF, also known as complement control protein repeats (CCPs), is contained in four repeating units of approximately 61 amino acids.
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