C2

Complement component C1 is a large inactive protein complex in the plasma, which is composed of one C1q, two C1r, and two C1s. The C1q subunit can bind to the Fc regions of two antigen-specific antibodies that have bound in close proximity to antigen fixed on the surface of a pathogen. Binding of the C1q subunit activates the C1r subunits and then C1s subunits are activated. Following, the activated C1s subunits can cleave serum C4 into C4a and C4b. Then after a series of reactions, the C3 convertase and C5 convertase formed and classical pathway is activated. C1q is made up of six heterotrimers each containing the C1qA, C1qB, and C1qC chains. Each chain of C1q has a central region forming a collagen stem together with the equivalent regions of the other two chains. The structures of C1r and C1s are similar, and both of them have the domain architecture CUB1-EGF-CUB2-CCP1-CCP2-SP. Recently, several researchers have found broad C1 functions beyond the complement system. C1q binds to the Frizzled receptors to activate C1s, which cleaves lipoprotein receptor-related protein 6 to trigger aging-associated Wnt receptor signaling. Beside, C1q binds to apoptotic cells and the activated C1 proteases cleave nuclear antigens.
Loading...
Clear All
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-783
Isotype IgG2aκ
Applications WB; ELISA; IHC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-199
Isotype IgG1κ
Applications ELISA; WB
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-485
Isotype IgG2bκ
Applications ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-24
Isotype IgG2a Lambda
Applications ELISA
Host Animal Goat
Specie Reactivity Human
Isotype IgG
Applications WB; IP; ELISA
Host Animal Rabbit
Specie Reactivity Human
Isotype IgG
Applications WB; IF
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-566
Isotype IgG1κ
Applications ELISA
Host Animal Goats
Isotype IgG
Applications Western Blots; ELISA; Immunodiffusion
Host Animal Rabbit
Specie Reactivity Human
Antibody Clone TJL-27
Isotype IgG
Applications ELISA
Host Animal Rabbit
Specie Reactivity Human
Antibody Clone TJL-28
Isotype IgG
Applications ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-29
Isotype IgG2A
Applications WB; IP
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications WB; IP; IF; IHC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications IP
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications WB; IHC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications WB; IF; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications WB; IF; FCM
Clear All
Specie Reactivity Human
Sensitivity 2.7 ng/mL (7.8-500 ng/mL)
Applications ELISA
Specie Reactivity Human
Sensitivity 15.6 ng/mL (15.6-250 ng/mL)
Applications ELISA
Specie Reactivity Mouse
Sensitivity 18.75 ng/mL (18.75-300 ng/mL)
Applications ELISA
Specie Reactivity Rat
Sensitivity 0.07 ng/mL (0.19-12 ng/mL)
Applications ELISA
Specie Reactivity Chicken
Sensitivity 0.375 ng/mL (6.25-400 ng/mL)
Applications ELISA
Specie Reactivity Rabbit
Sensitivity 0.1 ng/mL (1.0-25 ng/mL)
Applications ELISA
Specie Reactivity Bovine
Sensitivity 7.8 ng/mL (15.6-1000 ng/mL)
Applications ELISA
Specie Reactivity Guinea Porcine
Sensitivity 0.1 ng/mL (1.0-25 ng/mL)
Applications ELISA
Specie Reactivity Dog
Sensitivity 0.1 ng/mL (1.0-25 ng/mL)
Applications ELISA
Specie Reactivity Monkey
Sensitivity 0.188 ng/mL (0.313-20 ng/mL)
Applications ELISA
Clear All
Specie Reactivity Human
Type Recombinant Enzyme
Expression Host Mouse myeloma cell line, NS0
Applications Enzyme Activity Assays
Specie Reactivity Human
Type Recombinant Protein
Expression Host E. Coli
Applications WB; ELISA; IP
Specie Reactivity Rat
Type Recombinant Protein
Expression Host E. Coli
Applications WB; ELISA; IP
Specie Reactivity Mouse
Type Recombinant Enzyme
Expression Host Mouse myeloma cell line, NS0
Applications Enzyme Activity Assays
Specie Reactivity Human
Type Native Protein
Applications Functional Assays
Specie Reactivity Mouse
Type Recombinant Protein
Expression Host Yeast
Applications WB; ELISA
Specie Reactivity Mouse
Type Recombinant Protein
Expression Host E.coli/Mammalian cell/Baculovirus
Applications WB; ELISA
Clear All
Specie Reactivity Mammalian
Purity >90%
Applications Blocking; IHC; WB
Specie Reactivity Mammalian
Purity >90%
Applications Blocking; IHC; WB
Specie Reactivity Human
Purity >90%
Applications Blocking; WB
Specie Reactivity Human
Purity >90%
Applications Blocking; WB
Specie Reactivity Human; Hamster
Purity >90%
Applications Blocking
Specie Reactivity Human; Mouse;Rat
Purity >90%
Applications IHC; WB
Specie Reactivity Human; Mouse;Rat
Purity >90%
Applications IHC; WB
Specie Reactivity Human
Species of Lysate Escherichia coli (E. coli)
Application Western Blotting (WB); Control (Ct)
Specie Reactivity Human
Species of Lysate 293T Cells
Application Western Blotting (WB)
Specie Reactivity Human
Species of Lysate 293T Cells
Application Western Blotting (WB)
Specie Reactivity Human
Species of Lysate Human Cells
Application Western Blotting (WB)
Specie Reactivity Mouse
Species of Lysate Human Cells
Application Western Blotting (WB)
Clear All
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-mGFP
Tag mGFP
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-XL4
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Specie Reactivity Mouse
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Mouse
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Mouse
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Mouse
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Mouse
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Mouse
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag GFP
Specie Reactivity Mouse
Type Expression Plasmid
Vector PCMV6-Kan/Neo
Specie Reactivity Rat
Type Expression Plasmid
Vector pCMV6-Entry
Specie Reactivity Rat
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Rat
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Rat
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Rat
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Rat
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag GFP
For Research Use Only.