The complement system engages a tightly regulated network of plasma proteins, cell surface receptors, and regulators. In this system, complement C3 acts as a specifically versatile role via keeping the cascade alert, and it is a point of convergence of activation pathways, fueling the amplification of the complement response, exerting direct effector functions, and helping to coordinate downstream immune responses. Recently, some researches showed that naturally engages the power of C3 has important functions in many homeostatic processes, such as tissue regeneration and synapse pruning to clearing debris and controlling tumor cell progression. Meanwhile, due to its central position in immune surveillance, C3 became a target for microbial immune evasion and, if improperly engaged, a trigger point for a variety of clinical conditions.
C3 has displayed substantial correlations with obesity, and high gene expression of C3 has been reported in omental adipose tissue in obese men. Besides, it has been demonstrated that the cleavage product of C3, acylation-stimulating protein (ASP), is a paracrine metabolic factor that stimulates the uptake of glucose and fat storage in human adipose tissue. ASP deficiency in mice has been shown to be related to resistance to weight gain on a high-fat diet, despite improved food intake.
Fig.1 C3 protein.Distributed under CC BY-SA 3.0, from Wiki, without modification.
C3 Functional Service
Creative Biolabs provides a comprehensive range of Complement C3-related products, encompassing anti-C3 Antibodies, C3 ELISA Assay Kits, C3 Proteins and anti-C3 Aptamer. These products are ideal for studying complement activation, immune responses, and C3-related diseases, offering high specificity and reliability in various functional research.
Fig.2 Involvement of C3 in the complement system activation.1
Complement C3 function or activity testing is designed to assess the functional integrity and activity level of C3, a crucial component of the complement system. This test involves using various methods such as ELISA, western blotting, and hemolytic assays to evaluate the ability of C3 to undergo activation and participate in the immune cascade. The test can help identify defects in C3 activity linked to complement-mediated diseases like autoimmune disorders, infections, and inflammatory conditions. Our high quality C3 products can be well suited for these technologies. Research has shown that C3 activity testing can aid in diagnosing conditions such as age-related macular degeneration (AMD) and systemic lupus erythematosus (SLE), providing insights into disease pathogenesis and potential therapeutic targets.
Creative Biolabs provides C3-functional services, including custom assay development, C3 activity analysis, aiding customers design and executing experiments, analyzing data, and interpreting results. Our expert team, combined with advanced facilities, ensures the delivery of accurate and high-quality C3 functional testing services.
Click the following targets to view our C3 product lists.
Reference
Han, Juqiang, and Xiang Zhang. "Complement component C3: A novel biomarker participating in the pathogenesis of non-alcoholic fatty liver disease." Frontiers in Medicine 8 (2021): 653293. Distributed under Open Access license CC BY 4.0, without modification.
INQUIRY
Datasheet
Fig.1 C3 protein.
Fig.2 Involvement of C3 in the complement system activation.1
