Creative Biolabs insists on providing convenient and comprehensive complement-related experimental solutions for customers from all over the world with a professional and rigorous scientific spirit. The high-level technical platform and high-quality service are well-received by clients from all over the world.
The classical pathway (CP) of complement was the first to be discovered scientifically and is also the most intensively studied pathway. The CP of complement refers to the combination of activator and C1q, sequential activation of C1r, Cls, C4, C2, C3, forming a cascade enzymatic reaction process of C3 convertase (C4b2a) and C5 convertase (C4b2a3b). The functional detection of the classical pathway will provide important and irreplaceable data support for studies related to complement activation. Here, we briefly summarize the protocols for the detection of CP in complement in order to assist your related research.
Hemolytic Assay for the Analysis of the CP of Complement
Traditionally, complement activation has been analyzed using hemolytic assays which provide information about the integrity of the entire complement cascade.
Fig 1. Workflow of hemolytic assay for functional analysis of the CP.
ELISA-Based Assay for the Analysis of the CP of Complement
ELISA-based detection methods also provide reliable information for complement function detection.
Fig 2. Workflow of ELISA-based assay for functional analysis of the CP.
Equipped with advanced and complete biological experimental equipment and cutting-edge technical theory, Creative Biolabs upholds the spirit of scientific rigor to provide one-stop complement-related research solutions for clients from all over the world. Successful research is inseparable from stable and accurate data support, and we have the ability to provide you with customizable, scalable and easy-to-access classical complement pathway function detection experiments and provide accurate and repeatable data output. With our support, trust that you can advance your research project more effectively and take immunology research to a next level.
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