In Vitro ADME Screening Service
Creative Biolabs' service is engineered to provide decisive, data-driven answers early in discovery. Our primary mission is to de-risk candidate molecules, significantly reducing the probability of costly late-stage failure. We deliver predictive human pharmacokinetic (PK) parameters, allowing your medicinal chemistry teams to engage in targeted structure-activity relationship (SAR) optimization from the initial hit stage. Whether you need to assess absorption, distribution, metabolism, or excretion (ADME) properties, we have the expertise and technology to deliver the answers you need.
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Specialized ADME Profiling for Therapeutic Antibodies
In vitro ADME screening assays for therapeutic antibodies and proteins are critical for evaluating the pharmacokinetic properties of these biologics. These assays help predict how the antibodies or proteins will behave in the body, aiding in drug development and optimization. Our team of highly skilled scientists is dedicated to providing the most accurate and reliable results possible. We understand that each therapeutic antibody or protein is unique, and therefore, we tailor our assays to meet the specific requirements of your project.
Discover how we can help - Request a consultation to discuss your specific lead optimization challenges.
Fig.1 Schematic of ADME. 1
What We Can Offer
Our common in vitro ADME screening assays include:
Physicochemical Property
We provide solubility studies to assess the drug solubility in different solvents, pH conditions, temperature ranges, and other parameters to optimize its formulation and bioavailability.
Permeability
We provide Caco-2 permeability, MDCK-MDR1 permeability, and parallel artificial membrane permeability assay to evaluate the permeability of drugs.
Metabolic Stability
Metabolic stability assays assess the drug candidate's metabolic stability and its potential for drug-drug interactions by measuring its metabolism.
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Protein Binding
These assays evaluate the extent to which a drug candidate binds to plasma proteins, which can impact its bioavailability and distribution in the body.
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Enzyme Inhibition
Our enzyme inhibition assays evaluate a drug's ability to inhibit enzyme activity, such as cytochrome P450 (CYP) enzymes.
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Enzyme Induction
We provide enzyme induction assays to assess a drug's potential to induce enzyme expression, which plays a critical role in the evaluation of drug-drug interactions.
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Reaction phenotyping
Our services help to identify the metabolic enzymes of a particular drug, determine which enzymes are involved in metabolism, and predict potential drug-drug interactions.
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Transporter
We provide comprehensive transporter interaction assessment, including a variety of essential ABC transporters and SLC transporters.
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Our In Vitro ADME Screening Service
Highlights
Ethical & Predictive Modeling
We provide high-quality in vitro data that integrates seamlessly with your in silico models. This approach significantly reduces reliance on costly animal studies, aligning your project with the global ethical 3Rs strategy.
Advanced Assay Portfolio
Our comprehensive screening goes beyond the standard CYP450 panel. We include specialized phase II (UGT) enzyme assays, hepatic uptake, and lysosomal trapping models to cover all critical metabolic and distribution liabilities.
Actionable SAR Guidance
Our expert team translates raw data into clear, actionable recommendations for optimizing your structure-activity relationship. This expertise guides your molecular design decisions.
Automation & High-Throughput
Our services utilize fully automated liquid handling systems and sensitive LC-MS/MS platforms. This technological power delivers rapid, reproducible results, enabling high-throughput screening and faster lead candidate prioritization.
Experience the Creative Biolabs advantage - Get a quote today and witness the power of high-fidelity ADME data.
Customer Reviews
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Increased Throughput
Using Creative Biolabs' in vitro ADME screening service in our research has significantly improved/facilitated the triage of thousands of novel small molecules, enabling us to eliminate poorly permeable candidates rapidly. - Dr. Mar*** G.
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Critical DDI Mitigation
The reaction phenotyping and enzyme interaction assays provided by Creative Biolabs were instrumental. They identified major clearance pathways, allowing us to proactively modify the structure to eliminate a critical DDI risk that we had initially underestimated. - Dr. Lau*** S.
FAQs
Q: How do I ensure predictive quality when moving from in vitro data to in vivo human predictions?
A: Our team employs sophisticated IVIVE models to translate parameters into predicted human PK. We account for critical factors like unbound drug concentrations and blood flow. We encourage you to reach out to our modeling experts for a deeper dive into our predictive methodologies.
Q: Can your assays handle compounds with very low aqueous solubility?
A: Yes. We use specialized techniques, including optimized cosolvent systems and concentration adjustments, to ensure that test compounds remain appropriately solubilized during the assay. We also provide Kinetic and Thermodynamic Solubility assays upfront to help you define the safe working range.
Related Services
Kinetic Solubility Testing Service
High-throughput testing of key physical properties and stability to predict developability risks early, complementing your ADME results.
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Thermodynamic Solubility Testing Service
Essential testing of foundational physical properties to determine the compound's intrinsic potential for absorption, formulation success, and bioavailability prediction early in discovery.
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How to Contact Us
At Creative Biolabs, we are committed to providing state-of-the-art and effective ADME solutions. Our high-throughput ADME screening platforms are equipped with advanced instrumentation and automated sample-handling systems. Contact us today to learn more about our in vitro ADME screening assays and how we can help you take your therapeutic antibodies or proteins to the next level.
Reference
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Hasan, Md Rifat et al. "Application of Mathematical Modeling and Computational Tools in the Modern Drug Design and Development Process." Molecules (Basel, Switzerland) vol. 27,13 4169. 29 Jun. 2022. Distributed under an Open Access license CC BY 4.0, without modification. https://doi.org/10.3390/molecules27134169
For Research Use Only | Not For Clinical Use
