In Vitro ADME

Performing early in vitro ADME test is a way to better understand the absorption, distribution, mode of action (MOA) metabolism, excretion (ADME) and pharmacokinetic (PK) properties of a compound. These properties are very critical for selecting the proper drug candidates for later experiments.

Creative Biolabs offers a comprehensive range of tailored in vitro ADME services, including professional testing design, GLP-based in vitro ADME testing and data analysis, to help you characterize the ADME properties of your drug candidate and its interaction function. Our experienced team has strong problem-solving skills that enable us to perform a variety of in vitro ADME tests and assist clients to come up with a solution that suits their drug discovery needs.

Our Complete Suite of In Vitro ADME Services Includes:

Metabolic Stability
  • Microsomes
  • Hepatocytes
  • S9 Fractions
  • Plasma Binding Stability
  • Metabolic Pathway and Metabolites Identification
Distribution
  • CaCo-2 & MDCK Permeability
  • PAMPA (GIT, BBB and Skin)
  • Influx Transporters
  • Plasma / Blood Partitioning
  • Blood Brain Barrier Penetration
Drug-Drug Interactions
  • CYP450 Inhibition
  • CYP450 Induction
  • CYP450 Reaction Phenotyping
  • Reactive Metabolite Screening
Others
  • Solubility
  • Log P & Log D
  • Cell Proliferation & Cytoxicity
  • Mechanism PK Study
  • In Vitro Toxicity
  • hERG Inhibition

Highlights at Creative Biolabs:

  • Guarantee: further action will only be taken when the previous step is succeeding.
  • A wide range of solutions: we have come up with a complete pipeline to provide you with flexible options.
  • State-of-the-art equipment: your project deserves the best equipment in the field.

Creative Biolabs's years of expertise and propriety LC-MS-MS-based technologies enable us to gain insight into your ADME analysis development, accelerate your data collection, and help you interpret the results. We are devoted to accelerating and enhancing your drug discovery, allowing you to identify the most promising hit compounds for next immunotherapy-based cancer treatment.

For more information, please contact us.

For Research Use Only | Not For Clinical Use

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